The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida so, conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).
Anticandidal activity of SPA-S-843, a new polyenic drug / Strippoli, Vittorio; D'Auria, Felicia Diodata; Simonetti, Giovanna; T., Bruzzese; Simonetti, Nicola. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 45:2(2000), pp. 235-237. [10.1093/jac/45.2.235]
Anticandidal activity of SPA-S-843, a new polyenic drug
STRIPPOLI, Vittorio;D'AURIA, Felicia Diodata;SIMONETTI, Giovanna;SIMONETTI, Nicola
2000
Abstract
The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida so, conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
