Aims-To investigate whether diabetic retinopathy (DR), already associated with microvascular alterations, ischaemia, and endothelial dysfunction, was also characterised by abnormal modulation of coagulation pathways. Methods-Plasma samples, collected from 67 type 1 diabetics comparable for age, duration of disease (DD), and metabolic control (MC), were processed for prothrombin degradation products (F1+2) and factor VII coagulant activity (FVII:c). 50 normal subjects served as a control group. The ETDRS-Airlie House Classification of DR was used. Results-A significant correlation between FVII:c and F1+2 plasma concentrations was observed (p <0.05). FVII:c (p <0.005) and F1+2 (p <0.0001) levels were higher in diabetics than in controls, especially in patients with proliferative DR (FVII:c p <0.0001; F1+2 p<0.005). However, cases without retinal lesions and healthy subjects did not differ significantly (FVII:c and F1+2 p >0.05). Conclusions-These findings pointed out the presence of a hypercoagulable state associated with endothelial dysfunction in patients with insulin dependent diabetes mellitus (IDDM), demonstrated both by increased FVII:c and F1+2 plasma levels. Moreover, the observation of different DR related degrees of procoagulant activity, despite comparable DD and IMC, strengthens the hypothesis of multiple risk factors in the pathogenesis of DR.

Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients / C., Giusti; R., Schiaffini; C., Brufani; A., Pantaleo; Vingolo, Enzo Maria; Gargiulo, Patrizia. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - STAMPA. - 84:6(2000), pp. 591-595. ((Intervento presentato al convegno Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology tenutosi a FT LAUDERDALE, FLORIDA nel MAY 10-15, 1998 [10.1136/bjo.84.6.591].

Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients

VINGOLO, Enzo Maria;GARGIULO, Patrizia
2000

Abstract

Aims-To investigate whether diabetic retinopathy (DR), already associated with microvascular alterations, ischaemia, and endothelial dysfunction, was also characterised by abnormal modulation of coagulation pathways. Methods-Plasma samples, collected from 67 type 1 diabetics comparable for age, duration of disease (DD), and metabolic control (MC), were processed for prothrombin degradation products (F1+2) and factor VII coagulant activity (FVII:c). 50 normal subjects served as a control group. The ETDRS-Airlie House Classification of DR was used. Results-A significant correlation between FVII:c and F1+2 plasma concentrations was observed (p <0.05). FVII:c (p <0.005) and F1+2 (p <0.0001) levels were higher in diabetics than in controls, especially in patients with proliferative DR (FVII:c p <0.0001; F1+2 p<0.005). However, cases without retinal lesions and healthy subjects did not differ significantly (FVII:c and F1+2 p >0.05). Conclusions-These findings pointed out the presence of a hypercoagulable state associated with endothelial dysfunction in patients with insulin dependent diabetes mellitus (IDDM), demonstrated both by increased FVII:c and F1+2 plasma levels. Moreover, the observation of different DR related degrees of procoagulant activity, despite comparable DD and IMC, strengthens the hypothesis of multiple risk factors in the pathogenesis of DR.
coagulation pathways; diabetic retinopathy; insulin dependent diabetic patients
01 Pubblicazione su rivista::01a Articolo in rivista
Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients / C., Giusti; R., Schiaffini; C., Brufani; A., Pantaleo; Vingolo, Enzo Maria; Gargiulo, Patrizia. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - STAMPA. - 84:6(2000), pp. 591-595. ((Intervento presentato al convegno Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology tenutosi a FT LAUDERDALE, FLORIDA nel MAY 10-15, 1998 [10.1136/bjo.84.6.591].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/252289
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