Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information From the intact system.

Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements / Capuani, Giorgio; Miccheli, Alfredo; Tomassini, Alberta; L., Falasca; T., Aureli; Conti, Filippo. - In: ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY. - ISSN 1073-1199. - 28:4(2000), pp. 293-305. [10.3109/10731190009119360]

Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements

CAPUANI, Giorgio;MICCHELI, Alfredo;TOMASSINI, Alberta;CONTI, Filippo
2000

Abstract

Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying matemathical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agrement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information From the intact system.
2000
alginate; gel beads; hepatocytes; magnetic resonance imaging; magnetic-resonance; microcapsules; perfused cells; separation; spectroscopy; spheroids; time; water; water diffusion bioartificial liver
01 Pubblicazione su rivista::01a Articolo in rivista
Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements / Capuani, Giorgio; Miccheli, Alfredo; Tomassini, Alberta; L., Falasca; T., Aureli; Conti, Filippo. - In: ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY. - ISSN 1073-1199. - 28:4(2000), pp. 293-305. [10.3109/10731190009119360]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/251808
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