To better understand the biosynthesis of guanidinosuccinic acid, we determined urea, arginine, and guanidinosuccinic acid levels in nondialyzed uremic and hyperargininemic patients. These substances were also determined during several years of therapy in one hyperargininemic patient. Interrelationships of guanidinosuccinic acid levels with their corresponding urea and arginine levels were assessed by linear correlation studies. In uremic patients, a significant positive linear correlation (r = .821, p < .001) was found between serum urea and guanidinosuccinic acid levels. A significant positive linear correlation was also found between serum urea levels and urinary guanidinosuccinic acid levels (r = .828, P < .001), but not between serum arginine levels and urinary guanidinosuccinic acid levels in hyperargininemic patients. In the intrahyperargininemic patient study, a similar significant positive correlation was found between serum urea levels and the corresponding urinary guanidinosuccinic acid levels (r = .866, P < .001); the correlation between serum arginine levels and the corresponding urinary guanidinosuccinic acid levels was smaller. The presented analytical findings in uremic and hyperargininemic patients clearly demonstrate a metabolic relationship between urea and guanidinosuccinic acid.
THE PATHOBIOCHEMISTRY OF UREMIA AND HYPERARGININEMIA FURTHER DEMONSTRATES A METABOLIC RELATIONSHIP BETWEEN UREA AND GUANIDINOSUCCINIC ACID / Bart, Marescau; Peter P., De Deyn; Ijaz A., Qureshi; Marc E., De Broe; Antonozzi, Italo; Stephen D., Cederbaum; Roberto, Cerone; Nestor, Chamoles; Rosa, Gatti; Soo Sang, Kang. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 41:9(1992), pp. 1021-1024. [10.1016/0026-0495(92)90131-s]
THE PATHOBIOCHEMISTRY OF UREMIA AND HYPERARGININEMIA FURTHER DEMONSTRATES A METABOLIC RELATIONSHIP BETWEEN UREA AND GUANIDINOSUCCINIC ACID
ANTONOZZI, Italo;
1992
Abstract
To better understand the biosynthesis of guanidinosuccinic acid, we determined urea, arginine, and guanidinosuccinic acid levels in nondialyzed uremic and hyperargininemic patients. These substances were also determined during several years of therapy in one hyperargininemic patient. Interrelationships of guanidinosuccinic acid levels with their corresponding urea and arginine levels were assessed by linear correlation studies. In uremic patients, a significant positive linear correlation (r = .821, p < .001) was found between serum urea and guanidinosuccinic acid levels. A significant positive linear correlation was also found between serum urea levels and urinary guanidinosuccinic acid levels (r = .828, P < .001), but not between serum arginine levels and urinary guanidinosuccinic acid levels in hyperargininemic patients. In the intrahyperargininemic patient study, a similar significant positive correlation was found between serum urea levels and the corresponding urinary guanidinosuccinic acid levels (r = .866, P < .001); the correlation between serum arginine levels and the corresponding urinary guanidinosuccinic acid levels was smaller. The presented analytical findings in uremic and hyperargininemic patients clearly demonstrate a metabolic relationship between urea and guanidinosuccinic acid.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
