New hydrogels obtained by a crosslinking reaction between the polycarboxylated derivative of scleroglucan (sclerox) and 1,6-hexanedibromide have been prepared and characterized. Different ratios between the alkane dihalide and sclerox yielded products with appreciably different properties, Water uptake by the hydrogel with a low degree of crosslinking was remarkably affected by ionic strength, The diffusion of a model molecule (theophylline) through the swelled crosslinked polymers was studied and the theoretical analysis leading to the calculation of permeability coefficients in different environmental conditions is reported. Tablets prepared with one of the new hydrogels behaved as swellable monolithic systems suitable for sustained drug release. (C) 1999 Elsevier Science B.V All rights reserved.
Novel hydrogel system from scleroglucan: synthesis and characterization / Coviello, Tommasina; Mario, Grassi; Giuseppe, Rambone; Eleonora, Santucci; Carafa, Maria; Evelina, Murtas; Fulvio M., Riccieri; Alhaique, Franco. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 60:(1999), pp. 367-378. [10.10.1016/S0168-3659(99)00091-7 |]
Novel hydrogel system from scleroglucan: synthesis and characterization
COVIELLO, Tommasina;CARAFA, Maria;ALHAIQUE, Franco
1999
Abstract
New hydrogels obtained by a crosslinking reaction between the polycarboxylated derivative of scleroglucan (sclerox) and 1,6-hexanedibromide have been prepared and characterized. Different ratios between the alkane dihalide and sclerox yielded products with appreciably different properties, Water uptake by the hydrogel with a low degree of crosslinking was remarkably affected by ionic strength, The diffusion of a model molecule (theophylline) through the swelled crosslinked polymers was studied and the theoretical analysis leading to the calculation of permeability coefficients in different environmental conditions is reported. Tablets prepared with one of the new hydrogels behaved as swellable monolithic systems suitable for sustained drug release. (C) 1999 Elsevier Science B.V All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
