A simple and rapid preparation of non-ionic surfactant vesicles is reported. These vesicles were obtained by sonication of appropriate mixtures of polyoxyethylene sorbitan-monolaurate (Tween 20) and cholesterol. The effect of the Tween 20/cholesterol ratio on the overall yield of non-ionic surfactant vesicles and on vesicle dimension and stability at different temperatures was investigated. Electron micrographs and fluorescence anistropy measurements showed that the obtained vesicles have a bilayer structure similar to that of liposomes. Non-ionic surfactant vesicles loaded with hydrophilic and lipophilic model molecules showed entrapment efficiency values comparable to those of phospholipid small unilamellar vesicles.
Vesicles from POLYSORBATE 20 AND CHOLESTEROL: A SIMPLE PREPARATION AND CHARACTERIZATION / Santucci, Eleonora; Carafa, Maria; Coviello, Tommasina; Murtas, Evelina; Riccieri, Fulvio Maria; Alhaique, Franco; Modesti, A; Modica, A.. - In: STP PHARMA SCIENCES. - ISSN 1157-1489. - 6:(1996), pp. 29-32.
Vesicles from POLYSORBATE 20 AND CHOLESTEROL: A SIMPLE PREPARATION AND CHARACTERIZATION
SANTUCCI, Eleonora;CARAFA, Maria;COVIELLO, Tommasina;MURTAS, Evelina;RICCIERI, Fulvio Maria;ALHAIQUE, Franco;
1996
Abstract
A simple and rapid preparation of non-ionic surfactant vesicles is reported. These vesicles were obtained by sonication of appropriate mixtures of polyoxyethylene sorbitan-monolaurate (Tween 20) and cholesterol. The effect of the Tween 20/cholesterol ratio on the overall yield of non-ionic surfactant vesicles and on vesicle dimension and stability at different temperatures was investigated. Electron micrographs and fluorescence anistropy measurements showed that the obtained vesicles have a bilayer structure similar to that of liposomes. Non-ionic surfactant vesicles loaded with hydrophilic and lipophilic model molecules showed entrapment efficiency values comparable to those of phospholipid small unilamellar vesicles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
