The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread / Santapaola, D; DEL CHIERICO, F; Petrucca, A; Uzzau, S; Casalino, M; Colonna, Bianca; Sessa, Rosa; Berlutti, Francesca; Nicoletti, M.. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - 188:(2006), pp. 1620-1627. [10.1128/JB.188.4.1620-1627.2006]

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread

PETRUCCA A;COLONNA, Bianca;SESSA, Rosa;BERLUTTI, Francesca;
2006

Abstract

The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread / Santapaola, D; DEL CHIERICO, F; Petrucca, A; Uzzau, S; Casalino, M; Colonna, Bianca; Sessa, Rosa; Berlutti, Francesca; Nicoletti, M.. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - 188:(2006), pp. 1620-1627. [10.1128/JB.188.4.1620-1627.2006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/239190
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