Background. The calcium sensitizer levosimendan protects against myocardial ischaemia and reperfusion injury in animal models. Methods. The present pilot study investigated whether a short infusion before coronary artery bypass grafting (CABG) would protect the myocardium and improve postoperative haemodynamics. Twenty-four patients with stable angina undergoing elective CABG surgery were randomized to receive either placebo or levosimendan (24 mg kg1) infused i.v. over a 10 min period just before placing the patient on cardiopulmonary bypass. Results. Perioperative haemodynamic variables, concentrations of cardiac troponin I over the 48 h postoperative period, and clinical outcomes were assessed. There were no adverse effects related to levosimendan. Compared with control patients, levosimendan-treated patients had lower postoperative troponin I concentrations (P0.05) and a higher cardiac index (P0.05). Conclusion. Patients receiving a short infusion of levosimendan before CABG showed evidence of less myocardial damage, suggestive of a preconditioning effect. Larger outcome studies are thus indicated to confirm benefit.

Preconditioning effects of levosimendan in coronary artery bypass grafting; a pilot study / Tritapepe, Luigi; DE SANTIS, V.; Vitale, D.; Santulli, Maria; Morelli, Andrea; Nofroni, Italo; Puddu, Paolo Emilio; Singer, M.; Pietropaoli, Paolo. - In: BRITISH JOURNAL OF ANAESTHESIA. - ISSN 0007-0912. - STAMPA. - 96:(2006), pp. 694-700. [10.1093/bja/ael082]

Preconditioning effects of levosimendan in coronary artery bypass grafting; a pilot study.

TRITAPEPE, Luigi;SANTULLI, Maria;MORELLI, Andrea;NOFRONI, Italo;PUDDU, Paolo Emilio;PIETROPAOLI, Paolo
2006

Abstract

Background. The calcium sensitizer levosimendan protects against myocardial ischaemia and reperfusion injury in animal models. Methods. The present pilot study investigated whether a short infusion before coronary artery bypass grafting (CABG) would protect the myocardium and improve postoperative haemodynamics. Twenty-four patients with stable angina undergoing elective CABG surgery were randomized to receive either placebo or levosimendan (24 mg kg1) infused i.v. over a 10 min period just before placing the patient on cardiopulmonary bypass. Results. Perioperative haemodynamic variables, concentrations of cardiac troponin I over the 48 h postoperative period, and clinical outcomes were assessed. There were no adverse effects related to levosimendan. Compared with control patients, levosimendan-treated patients had lower postoperative troponin I concentrations (P0.05) and a higher cardiac index (P0.05). Conclusion. Patients receiving a short infusion of levosimendan before CABG showed evidence of less myocardial damage, suggestive of a preconditioning effect. Larger outcome studies are thus indicated to confirm benefit.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
Preconditioning effects of levosimendan in coronary artery bypass grafting; a pilot study / Tritapepe, Luigi; DE SANTIS, V.; Vitale, D.; Santulli, Maria; Morelli, Andrea; Nofroni, Italo; Puddu, Paolo Emilio; Singer, M.; Pietropaoli, Paolo. - In: BRITISH JOURNAL OF ANAESTHESIA. - ISSN 0007-0912. - STAMPA. - 96:(2006), pp. 694-700. [10.1093/bja/ael082]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/238755
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