Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy / Antonella, Isgro; Mezzaroma, Ivano; Alessandro, Aiuti; Fantauzzi, Alessandra; Marcello, Pinti; Andrea, Cossarizza; Aiuti, Fernando. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 18:9(2004), pp. 1335-1337. [10.1097/00002030-200406180-00013]
Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy
MEZZAROMA, Ivano;FANTAUZZI, Alessandra;AIUTI, Fernando
2004
Abstract
Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
