Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy / Antonella, Isgro; Mezzaroma, Ivano; Alessandro, Aiuti; Fantauzzi, Alessandra; Marcello, Pinti; Andrea, Cossarizza; Aiuti, Fernando. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 18:9(2004), pp. 1335-1337. [10.1097/00002030-200406180-00013]

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

MEZZAROMA, Ivano;FANTAUZZI, Alessandra;AIUTI, Fernando
2004

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
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Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy / Antonella, Isgro; Mezzaroma, Ivano; Alessandro, Aiuti; Fantauzzi, Alessandra; Marcello, Pinti; Andrea, Cossarizza; Aiuti, Fernando. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 18:9(2004), pp. 1335-1337. [10.1097/00002030-200406180-00013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/237722
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