Case report. We report on a 7-year-old girl with generalized epilepsy and mental retardation. Discussion: Neurologic examination was normal and only facial dysmorphic features, compatible with frontonasal dysplasia, were observed. However, magnetic resonance imaging (MRI) revealed Chiari I malformation together with bilateral opercular polymicrogyria. To our knowledge, this is the first report of the association of these developmental disorders. This condition raises questions regarding the ethiopathogenetic classification of Chiari spectrum and as to whether embryologic and genetic causes could be potentially interconnected.
Bilateral perysilvian polymicrogyria in Chiari I malformation / Spalice, Alberto; Parisi, Pasquale; Mastrangelo, Mario; F., DE LUCA; A., Verrotti; Iannetti, Paola. - In: CHILDS NERVOUS SYSTEM. - ISSN 0256-7040. - STAMPA. - 22:12(2006), pp. 1635-1637. [10.1007/s00381-006-0180-x]
Bilateral perysilvian polymicrogyria in Chiari I malformation
SPALICE, ALBERTO
;PARISI, Pasquale;MASTRANGELO, Mario;IANNETTI, Paola
2006
Abstract
Case report. We report on a 7-year-old girl with generalized epilepsy and mental retardation. Discussion: Neurologic examination was normal and only facial dysmorphic features, compatible with frontonasal dysplasia, were observed. However, magnetic resonance imaging (MRI) revealed Chiari I malformation together with bilateral opercular polymicrogyria. To our knowledge, this is the first report of the association of these developmental disorders. This condition raises questions regarding the ethiopathogenetic classification of Chiari spectrum and as to whether embryologic and genetic causes could be potentially interconnected.File | Dimensione | Formato | |
---|---|---|---|
Spalice_Bilateral-perysilvian_2006.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
137.26 kB
Formato
Adobe PDF
|
137.26 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.