Monoclonal gammopathy of neurological significance (MGNS) is a rare condition characterized by peripheral neuropathy associated with a monoclonal gammopathy. We report the case of a 61-year-old man with IgM kappa monoclonal gammopathy and anti-MAG antibody-associated sensorimotor polyneuropathy. Treatment with rituximab and plasmapheresis resulted in clinical improvement but limited biochemical and electrophysiological response. The case illustrates the clinical complexity of MGNS and the challenges associated with its management.
Monoclonal gammopathy of neurological significance: a case report and a novel approach / Biglietto, M., Gherardini, M., Maglione, R., Anna Romeo, A., Fiori, L., Giovangrossi, P., Pulsoni, A., Coppetelli, U.. - In: MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES. - ISSN 2035-3006. - (2025). [10.4084/MJHID.2025.034]
Monoclonal gammopathy of neurological significance: a case report and a novel approach
Mario Biglietto
Primo
;Martina Gherardini;Raffaele Maglione;Luciano Fiori;Alessandro Pulsoni;
2025
Abstract
Monoclonal gammopathy of neurological significance (MGNS) is a rare condition characterized by peripheral neuropathy associated with a monoclonal gammopathy. We report the case of a 61-year-old man with IgM kappa monoclonal gammopathy and anti-MAG antibody-associated sensorimotor polyneuropathy. Treatment with rituximab and plasmapheresis resulted in clinical improvement but limited biochemical and electrophysiological response. The case illustrates the clinical complexity of MGNS and the challenges associated with its management.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
