The coexistence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) is a rare clinical condition with limited therapeutic evidence. We report the case of a 58-year-old patient with CLL diagnosed in 2016 and MM in 2022, requiring simultaneous treatment of both diseases. The patient was treated with venetoclax, bortezomib, and dexamethasone (Ven-Vd), achieving a complete response of MM and a partial response of CLL after eight cycles. This case highlights the potential efficacy of Ven-Vd in patients with concomitant CLL and MM.
A case of Multiple Myeloma in a patient in treatment for Chronic Lymphocytic Leukemia / Biglietto, M., Coppetelli, U., Fiori, L., Gherardini, M., Maglione, R., Pulsoni, A., Anna Romeo, A.. - In: MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES. - ISSN 2035-3006. - (2025). [10.4084/MJHID.2025.033]
A case of Multiple Myeloma in a patient in treatment for Chronic Lymphocytic Leukemia
Mario Biglietto
Primo
;Luciano Fiori;Martina Gherardini;Raffaele Maglione;Alessandro Pulsoni;
2025
Abstract
The coexistence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) is a rare clinical condition with limited therapeutic evidence. We report the case of a 58-year-old patient with CLL diagnosed in 2016 and MM in 2022, requiring simultaneous treatment of both diseases. The patient was treated with venetoclax, bortezomib, and dexamethasone (Ven-Vd), achieving a complete response of MM and a partial response of CLL after eight cycles. This case highlights the potential efficacy of Ven-Vd in patients with concomitant CLL and MM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
