Heartfailure andcardiovasculardisordersrepresenttheleadingcauseofdeathindiabeticpatients.Herewepresent a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect themechanismsofthiscomplexdisease,weconcludewithasectiononthemostrecent updates of the literature on clinical management.
Heart failure in diabetes / Jankauskas, Ss; Kansakar, U; Varzideh, F; Wilson, S; Mone, P; Lombardi, A; Gambardella, J; Santulli, G. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 125:(2021). [10.1016/j.metabol.2021.154910]
Heart failure in diabetes
Lombardi A;
2021
Abstract
Heartfailure andcardiovasculardisordersrepresenttheleadingcauseofdeathindiabeticpatients.Herewepresent a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect themechanismsofthiscomplexdisease,weconcludewithasectiononthemostrecent updates of the literature on clinical management.| File | Dimensione | Formato | |
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