In diabetic cardiomyopathy, interleukin-1 receptor associated kinase 2 (Irak2) translocates in the mitochondrion, where it triggers the recruitment of optic atrophy protein 1 (Opa1, also known as dynamin-like 120 kD protein) from the cristae junctions by prohibitin, destabilizing the organelle integrity and impairing its function. Complement factor D (Adipsin) inhibits the mitochondrial translocation of Irak2, eventually attenuating myocardial dysfunction.
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy / Jankauskas, S. S.; Varzideh, F.; Mone, P.; Kansakar, U.; Di Lorenzo, F.; Lombardi, A.; Santulli, G.. - In: MILITARY MEDICAL RESEARCH. - ISSN 2054-9369. - 11:1(2024). [10.1186/s40779-023-00506-3]
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
Lombardi A.Penultimo
Writing – Review & Editing
;
2024
Abstract
In diabetic cardiomyopathy, interleukin-1 receptor associated kinase 2 (Irak2) translocates in the mitochondrion, where it triggers the recruitment of optic atrophy protein 1 (Opa1, also known as dynamin-like 120 kD protein) from the cristae junctions by prohibitin, destabilizing the organelle integrity and impairing its function. Complement factor D (Adipsin) inhibits the mitochondrial translocation of Irak2, eventually attenuating myocardial dysfunction.| File | Dimensione | Formato | |
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