The Epstein-Barr virus (EBV) is the most common human virus, implicated in the pathogenesis of several human tumors, particularly B-cell lymphomas. 1 EBV-induced lymphoproliferative disorders are the result of the outgrowth of EBV-infected B cells that would normally be controlled by an effective EBV-specific cytotoxic T-cell response. 2, 3 The association between EBV and follicular lymphoma (FL) is not well recognized and only ten cases have been previously described. 4-7 Nine of them showed EBV-encoded small RNA (EBER)-positivity in> 75% of the tumor cells and one case in~ 5–10%. EBV-positivity was associated with grade 3 FL (9/10 cases), CD30 expression and rapid progression of disease. 6 However, it is still unclear whether EBV infection is an early event in the development of FL or a late event that haematologica 2019; 104: e269
Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature / Granai, Massimo; Raffaella Ambrosio, Maria; Akarca, Ayse; Mundo, Lucia; Vergoni, Federica; Santi, Raffaella; Mancini, Virginia; Di Stefano, Gioia; Amato, Teresa; Bellan, Cristiana; Puccini, Benedetta; Sorrentino, Ester; N Naresh, Kikkeri; Leoncini, Lorenzo; Marafioti, Teresa; Lazzi, Stefano. - In: HAEMATOLOGICA. - ISSN 0390-6078. - (2019). [10.3324/HAEMATOL.2018.215053]
Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature
Lucia Mundo;
2019
Abstract
The Epstein-Barr virus (EBV) is the most common human virus, implicated in the pathogenesis of several human tumors, particularly B-cell lymphomas. 1 EBV-induced lymphoproliferative disorders are the result of the outgrowth of EBV-infected B cells that would normally be controlled by an effective EBV-specific cytotoxic T-cell response. 2, 3 The association between EBV and follicular lymphoma (FL) is not well recognized and only ten cases have been previously described. 4-7 Nine of them showed EBV-encoded small RNA (EBER)-positivity in> 75% of the tumor cells and one case in~ 5–10%. EBV-positivity was associated with grade 3 FL (9/10 cases), CD30 expression and rapid progression of disease. 6 However, it is still unclear whether EBV infection is an early event in the development of FL or a late event that haematologica 2019; 104: e269I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
