: Patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show abnormally high delta (<4 Hz) and low alpha (8-12 Hz) rhythms measured from resting-state eyes-closed electroencephalographic (rsEEG) activity. Here, we hypothesized that the abnormalities in rsEEG activity may be greater in ADMCI patients than in those with MCI not due to AD (noADMCI). Furthermore, they may be associated with the diagnostic cerebrospinal fluid (CSF) amyloid-tau biomarkers in ADMCI patients. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 45), ADMCI (N = 70), and noADMCI (N = 45) participants. The rsEEG rhythms spanned individual delta, theta, and alpha frequency bands. The eLORETA freeware estimated cortical rsEEG sources. Posterior rsEEG alpha source activities were reduced in the ADMCI group compared not only to the Healthy group but also to the noADMCI group (p < 0.001). Negative associations between the CSF phospho-tau and total tau levels and posterior rsEEG alpha source activities were observed in the ADMCI group (p < 0.001), whereas those with CSF amyloid beta 42 levels were marginal. These results suggest that neurophysiological brain neural oscillatory synchronization mechanisms regulating cortical arousal and vigilance through rsEEG alpha rhythms are mainly affected by brain tauopathy in ADMCI patients.

Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease / Del Percio, Claudio; Lizio, Roberta; Lopez, Susanna; Noce, Giuseppe; Carpi, Matteo; Jakhar, Dharmendra; Soricelli, Andrea; Salvatore, Marco; Yener, Görsev; Güntekin, Bahar; Massa, Federico; Arnaldi, Dario; Famà, Francesco; Pardini, Matteo; Ferri, Raffaele; Carducci, Filippo; Lanuzza, Bartolo; Stocchi, Fabrizio; Vacca, Laura; Coletti, Chiara; Marizzoni, Moira; Taylor, John Paul; Hanoğlu, Lutfu; Yılmaz, Nesrin Helvacı; Kıyı, İlayda; Özbek-İşbitiren, Yağmur; D'Anselmo, Anita; Bonanni, Laura; Biundo, Roberta; D'Antonio, Fabrizia; Bruno, Giuseppe; Antonini, Angelo; Giubilei, Franco; Farotti, Lucia; Parnetti, Lucilla; Frisoni, Giovanni B; Babiloni, Claudio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 26:1(2025), pp. 1-34. [10.3390/ijms26010356]

Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease

Del Percio, Claudio;Lizio, Roberta;Lopez, Susanna;Carpi, Matteo;Jakhar, Dharmendra;Massa, Federico;Carducci, Filippo;Stocchi, Fabrizio;Coletti, Chiara;D'Antonio, Fabrizia;Giubilei, Franco;Babiloni, Claudio
2025

Abstract

: Patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show abnormally high delta (<4 Hz) and low alpha (8-12 Hz) rhythms measured from resting-state eyes-closed electroencephalographic (rsEEG) activity. Here, we hypothesized that the abnormalities in rsEEG activity may be greater in ADMCI patients than in those with MCI not due to AD (noADMCI). Furthermore, they may be associated with the diagnostic cerebrospinal fluid (CSF) amyloid-tau biomarkers in ADMCI patients. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 45), ADMCI (N = 70), and noADMCI (N = 45) participants. The rsEEG rhythms spanned individual delta, theta, and alpha frequency bands. The eLORETA freeware estimated cortical rsEEG sources. Posterior rsEEG alpha source activities were reduced in the ADMCI group compared not only to the Healthy group but also to the noADMCI group (p < 0.001). Negative associations between the CSF phospho-tau and total tau levels and posterior rsEEG alpha source activities were observed in the ADMCI group (p < 0.001), whereas those with CSF amyloid beta 42 levels were marginal. These results suggest that neurophysiological brain neural oscillatory synchronization mechanisms regulating cortical arousal and vigilance through rsEEG alpha rhythms are mainly affected by brain tauopathy in ADMCI patients.
2025
cerebrospinal fluid (CSF) biomarkers; exact low-resolution brain electromagnetic source tomography (eLORETA); mild cognitive impairment due to Alzheimer’s disease (ADMCI); resting-state electroencephalographic (EEG) rhythms
01 Pubblicazione su rivista::01a Articolo in rivista
Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease / Del Percio, Claudio; Lizio, Roberta; Lopez, Susanna; Noce, Giuseppe; Carpi, Matteo; Jakhar, Dharmendra; Soricelli, Andrea; Salvatore, Marco; Yener, Görsev; Güntekin, Bahar; Massa, Federico; Arnaldi, Dario; Famà, Francesco; Pardini, Matteo; Ferri, Raffaele; Carducci, Filippo; Lanuzza, Bartolo; Stocchi, Fabrizio; Vacca, Laura; Coletti, Chiara; Marizzoni, Moira; Taylor, John Paul; Hanoğlu, Lutfu; Yılmaz, Nesrin Helvacı; Kıyı, İlayda; Özbek-İşbitiren, Yağmur; D'Anselmo, Anita; Bonanni, Laura; Biundo, Roberta; D'Antonio, Fabrizia; Bruno, Giuseppe; Antonini, Angelo; Giubilei, Franco; Farotti, Lucia; Parnetti, Lucilla; Frisoni, Giovanni B; Babiloni, Claudio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 26:1(2025), pp. 1-34. [10.3390/ijms26010356]
File allegati a questo prodotto
File Dimensione Formato  
CSF.pdf

accesso aperto

Note: Del Percio_Resting-State_2025
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 3.16 MB
Formato Adobe PDF
3.16 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1731086
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact