Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic process, which could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a stress-responsive protein deacetylase and mono-ADP ribosyltransferase enzyme, blocks adipogenesis. Mutants of SIRT6 (N308K/A313S) were recently linked to the in the long lifespan Ashkenazi Jews. In this study, we aimed to clarify how these new centenarian-associated SIRT6 genetic variants affect adipogenesis at the transcriptional and epigenetic level.
Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant / Frohlich, Jan; Liorni, Niccolò; Mangoni, Manuel; Lochmanová, Gabriela; Pírek, Pavlína; Kaštánková, Nikola; Pata, Pille; Kucera, Jan; N Chaldakov, George; B Tonchev, Anton; Pata, Illar; Gorbunova, Vera; Leire, Eric; Zdráhal, Zbyněk; Mazza, Tommaso; Vinciguerra, Manlio. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - (2024).
Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
Jan Frohlich;Manuel Mangoni;Tommaso Mazza;Manlio Vinciguerra
2024
Abstract
Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic process, which could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a stress-responsive protein deacetylase and mono-ADP ribosyltransferase enzyme, blocks adipogenesis. Mutants of SIRT6 (N308K/A313S) were recently linked to the in the long lifespan Ashkenazi Jews. In this study, we aimed to clarify how these new centenarian-associated SIRT6 genetic variants affect adipogenesis at the transcriptional and epigenetic level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
