A NEW APPROACH TO PEDIATRIC BURNS: COMPARING STABLE OZONIDES AND SILVER SULPHADIAZINE

A NEW APPROACH TO PEDIATRIC BURNS: COMPARING STABLE OZONIDES AND SILVER SULPHADIAZINE Serena Crucianelli1 , Guido Ciprandi2 , Francesca Grussu2 , Francesco Spione2 , Paolo Dicorato2 , Mara Pisani3 1 Sapienza University of Rome, Internal Medicine and Medical Specialties, Roma, Italy 2 Bambino Gesù Children Hospital, Plastic and Maxillofacial surgery, Rome 3 Bambino Gesù Children Hospital, Emergency, Rome Introduction: Burns represent the most frequent acute wounds in pediatric population aged < 5. The most challenging aspects of children’s burn are the Lack of: -alternatives to silver sulphadiazine (SS) in children aged <12 months, face and mucosal burns. -child’s compliance painful and long dressing changes, requiring immobilization causing child and care givers’ distress -easy reproduceable dressing for home caring. In our study we compared a new approach to pediatric burns based on stable ozonides (SO) to SS cream. Methods: Out/inpatients aged 0-18 presenting with I to IIB grade burns despite multiplicity, location, are included in the study. Children treated in monotherapy with SO since the first dressing only are considered eligible. Treatment consisted of: -cleaning and cleansing with SO spray -Non adherent I dressing: Paraffin gauzes or tulle. -II dressing: non-woven gauzes or thin polyurethane foam in exudating wounds. -Cohesive bandage fixation. - Change: 12 or 24 hours depending on burn degree. -Caregiver education to SO application was provided Results are compared SS approach. At least 6 months follow-up for scarring sequelae is provided. Results: In 36 months, 80 children aged 4.2+/-2.8 out of 300 presenting with burns have been considered eligible. Outcomes are summarized on Table 1. No Adverse events, changes in pigmentation occurred. Educated care givers performed dressing change in home-caring reducing the need of child’s daily clinic admission. Time to re-epithelization was almost superimposable to SS but related safety issue in children aged <12 months, and above all pain, distress related to the mandatory dry cream debris removal were avoided. Conclusions: The new protocol based on SO for burns graded from I to IIB is a safe alternative even in neonates, periocular area and on mucosae allowing smooth reepithelization while lowering scarring sequelae rates. References: 1. Bertuccio, M. P., Rizzo, V., Arena, S., Trainito, A., Montalto, A. S., Caccamo, D., ... & Impellizzeri, P. (2023). Ozoile reduces the LPSinduced inflammatory response in colonic epithelial cells and THP-1 monocytes. Current Issues in Molecular Biology, 45(2), 1333-1348.