Aim: Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly. Materials and methods: We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization. Results: DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma. Conclusion: This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.
Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool / Alzoubi, H.; Gianno, F.; Abuelhaija, Y.; Najadat, A. A.; Mustafa, A.; Al-Arman, A. Y.; Al-Arman, L. Y.; Banihani, D.; Mustafa, A.; Abualdahab, N.; Broggi, G.; Gaggero, G.; Piol, N.; Fiaschi, P.; Miele, E.; Giangaspero, F.. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - 41:1(2022), pp. 12-17. [10.5414/NP301415]
Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool
Gianno F.;Mustafa A.;Mustafa A.;Miele E.;Giangaspero F.
2022
Abstract
Aim: Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly. Materials and methods: We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization. Results: DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma. Conclusion: This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.File | Dimensione | Formato | |
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34) Cerebellar liponeurocytoma in an elderly patient DNA.pdf
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