Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool

Aim: Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly. Materials and methods: We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization. Results: DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma. Conclusion: This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.