Objectives: Primary Sjögren's syndrome (pSS) is frequently associated with autoimmune thyroiditis (AT). The aim of this study was to evaluate the prevalence of AT in a national cohort of pSS and to describe the clinical and histological phenotype of patients with pSS and associated AT. Methods: In this multicentre cross-sectional study, data from 2546 pSS were collected and the presence of AT was reported. In a subgroup, the histology of minor salivary glands was evaluated. Differences between pSS with and without AT were evaluated. Results: A concomitant pSS and AT was detected in 19.6% of cases. Patients with pSS and AT displayed a lower prevalence of lymphoma, male sex and disease-modifying anti-rheumatic drugs (DMARDs) use and a higher prevalence of fibromyalgia, coeliac disease and hypergammaglobulinaemia. Multivariable analysis confirmed a higher prevalence of fibromyalgia and coeliac disease and lower use of DMARDs. In a subgroup of patients (n=232), a significantly higher focus score and number of foci was detected in pSS without AT (n=169) as compared to pSS with AT (n=54). Conclusions: This is the largest study evaluating the coexistence of pSS and AT. We confirm a high association between pSS and AT and describe the presence of a different phenotype characterized by a higher rate of celiac disease and fibromyalgia. Although not significant, the lower prevalence of both lymphoma and intake of DMARDs, along with a significantly lower focus score and number of foci, possibly suggest a more favourable outcome in concomitant pSS and AT which further deserve future investigations.

Clinical and histological features of patients with primary sjögren's syndrome and autoimmune thyroiditis. a national multicentre cross-sectional study / Colafrancesco, Serena; Celia, Alessandra Ida; Baldini, Chiara; Quartuccio, Luca; Bartoloni, Elena; Carubbi, Francesco; Orlandi, Martina; Barbati, Cristiana; Pignataro, Maria Gemma; Cerbelli, Bruna; Giordano, Carla; Ferro, Francesco; Gattamelata, Angelica; Giardina, Federico; Izzo, Raffaella; Longhino, Simone; De Vita, Salvatore; Gerli, Roberto; Giacomelli, Roberto; Conti, Fabrizio; Priori, Roberta. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 41:12(2023), pp. 2389-2396. [10.55563/clinexprheumatol/eh36vs]

Clinical and histological features of patients with primary sjögren's syndrome and autoimmune thyroiditis. a national multicentre cross-sectional study

Colafrancesco, Serena
;
Celia, Alessandra Ida;Barbati, Cristiana;Pignataro, Maria Gemma;Cerbelli, Bruna;Giordano, Carla;Ferro, Francesco;Gattamelata, Angelica;Giardina, Federico;Izzo, Raffaella;Conti, Fabrizio;Priori, Roberta
2023

Abstract

Objectives: Primary Sjögren's syndrome (pSS) is frequently associated with autoimmune thyroiditis (AT). The aim of this study was to evaluate the prevalence of AT in a national cohort of pSS and to describe the clinical and histological phenotype of patients with pSS and associated AT. Methods: In this multicentre cross-sectional study, data from 2546 pSS were collected and the presence of AT was reported. In a subgroup, the histology of minor salivary glands was evaluated. Differences between pSS with and without AT were evaluated. Results: A concomitant pSS and AT was detected in 19.6% of cases. Patients with pSS and AT displayed a lower prevalence of lymphoma, male sex and disease-modifying anti-rheumatic drugs (DMARDs) use and a higher prevalence of fibromyalgia, coeliac disease and hypergammaglobulinaemia. Multivariable analysis confirmed a higher prevalence of fibromyalgia and coeliac disease and lower use of DMARDs. In a subgroup of patients (n=232), a significantly higher focus score and number of foci was detected in pSS without AT (n=169) as compared to pSS with AT (n=54). Conclusions: This is the largest study evaluating the coexistence of pSS and AT. We confirm a high association between pSS and AT and describe the presence of a different phenotype characterized by a higher rate of celiac disease and fibromyalgia. Although not significant, the lower prevalence of both lymphoma and intake of DMARDs, along with a significantly lower focus score and number of foci, possibly suggest a more favourable outcome in concomitant pSS and AT which further deserve future investigations.
2023
sjӧgren’s syndrome; autoimmune thyroiditis; prevalence, clinical; histology; fibromyalgia; coeliac disease; DMARDs
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical and histological features of patients with primary sjögren's syndrome and autoimmune thyroiditis. a national multicentre cross-sectional study / Colafrancesco, Serena; Celia, Alessandra Ida; Baldini, Chiara; Quartuccio, Luca; Bartoloni, Elena; Carubbi, Francesco; Orlandi, Martina; Barbati, Cristiana; Pignataro, Maria Gemma; Cerbelli, Bruna; Giordano, Carla; Ferro, Francesco; Gattamelata, Angelica; Giardina, Federico; Izzo, Raffaella; Longhino, Simone; De Vita, Salvatore; Gerli, Roberto; Giacomelli, Roberto; Conti, Fabrizio; Priori, Roberta. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 41:12(2023), pp. 2389-2396. [10.55563/clinexprheumatol/eh36vs]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1706016
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