Primary breast lymphoma (PBL) is a rare form of extranodal non-Hodgkin's lymphoma (NHL), whose own specific biological characteristics still need to be fully defined. No significant prognostic factor has been found and the optimal therapeutic strategy is uncertain. However, an intensified systemic therapy has been advocated to prevent relapse, even in patients who show a complete response to local treatment. We report two cases of primary diffuse large B-cell breast lymphoma, review the literature about this topic, and discuss treatment options. We conclude that differential therapeutic strategies based on the risk of relapse associated with the International Prognostic Index (IPI) are a reasonable way to approach PBL, and can avoid undue toxicity deriving from treatment.

Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports / Stasi, R; Evangelista, Ml; Brunetti, M; Bussa, S; Maritati, R; Turrini, L; Taccogna, S; Crescenzi, A; Angelini, F.. - In: MEDICAL ONCOLOGY. - ISSN 1357-0560. - 26:1(2009), pp. 22-26.

Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports.

Crescenzi A;
2009

Abstract

Primary breast lymphoma (PBL) is a rare form of extranodal non-Hodgkin's lymphoma (NHL), whose own specific biological characteristics still need to be fully defined. No significant prognostic factor has been found and the optimal therapeutic strategy is uncertain. However, an intensified systemic therapy has been advocated to prevent relapse, even in patients who show a complete response to local treatment. We report two cases of primary diffuse large B-cell breast lymphoma, review the literature about this topic, and discuss treatment options. We conclude that differential therapeutic strategies based on the risk of relapse associated with the International Prognostic Index (IPI) are a reasonable way to approach PBL, and can avoid undue toxicity deriving from treatment.
2009
breast neoplasms; Antineoplastic Combined Chemotherapy Protocols; Immunohistochemistry
01 Pubblicazione su rivista::01i Case report
Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports / Stasi, R; Evangelista, Ml; Brunetti, M; Bussa, S; Maritati, R; Turrini, L; Taccogna, S; Crescenzi, A; Angelini, F.. - In: MEDICAL ONCOLOGY. - ISSN 1357-0560. - 26:1(2009), pp. 22-26.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1699952
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