Cases of association between celiac disease and wheat allergy have been described in the literature. However, to date, no reported cases have linked celiac disease with wheat food protein-induced enterocolitis syndrome (FPIES). We report a case of this association. A child diagnosed with celiac disease at the age of 2 years, following a gluten-free diet, experienced uncontrollable vomiting, and subsequent hypotension within 2 h of accidental ingestion of wheat flour. As a result, the child required hospitalization for fluid therapy. A similar episode occurred when the child turned 5 y, again resulting from accidental gluten ingestion. This time, the symptoms included vomiting, hypotension, and a loss of consciousness, leading to hospitalization for rehydration treatment. After this second episode, on suspicion of FPIES, the patient was referred to the pediatric allergists, who confirmed the diagnosis. To our knowledge, this is the first case of an association between celiac disease and FPIES. It has been hypothesized that exclusion diets in food-allergic children may lead to an increase in specific immunoglobulin E levels for those foods and, consequently, the risk of anaphylaxis. However, FPIES is not an immunoglobulin E-mediated condition. Hence, further investigations are warranted to elucidate the underlying mechanisms linking these 2 disorders. (c) 2023 The Author(s).

A possible unexpected link. Could wheat elimination trigger food protein-induced enterocolitis syndrome in a celiac disease patient? / Furio, Silvia; Mennini, Maurizio; Piccirillo, Marisa; Ferrari, Federica; Pacchiarotti, Claudia; Ferretti, Alessandro; Fiocchi, Alessandro Giovanni; Parisi, Pasquale; Di Nardo, Giovanni. - In: NUTRITION. - ISSN 0899-9007. - 118:(2024), pp. 1-3. [10.1016/j.nut.2023.112293]

A possible unexpected link. Could wheat elimination trigger food protein-induced enterocolitis syndrome in a celiac disease patient?

Furio, Silvia;Mennini, Maurizio;Piccirillo, Marisa;Pacchiarotti, Claudia;Ferretti, Alessandro;Parisi, Pasquale;Di Nardo, Giovanni
Ultimo
Writing – Original Draft Preparation
2024

Abstract

Cases of association between celiac disease and wheat allergy have been described in the literature. However, to date, no reported cases have linked celiac disease with wheat food protein-induced enterocolitis syndrome (FPIES). We report a case of this association. A child diagnosed with celiac disease at the age of 2 years, following a gluten-free diet, experienced uncontrollable vomiting, and subsequent hypotension within 2 h of accidental ingestion of wheat flour. As a result, the child required hospitalization for fluid therapy. A similar episode occurred when the child turned 5 y, again resulting from accidental gluten ingestion. This time, the symptoms included vomiting, hypotension, and a loss of consciousness, leading to hospitalization for rehydration treatment. After this second episode, on suspicion of FPIES, the patient was referred to the pediatric allergists, who confirmed the diagnosis. To our knowledge, this is the first case of an association between celiac disease and FPIES. It has been hypothesized that exclusion diets in food-allergic children may lead to an increase in specific immunoglobulin E levels for those foods and, consequently, the risk of anaphylaxis. However, FPIES is not an immunoglobulin E-mediated condition. Hence, further investigations are warranted to elucidate the underlying mechanisms linking these 2 disorders. (c) 2023 The Author(s).
2024
celiac disease; fpies; food allergy; ige; oral food challenge
01 Pubblicazione su rivista::01i Case report
A possible unexpected link. Could wheat elimination trigger food protein-induced enterocolitis syndrome in a celiac disease patient? / Furio, Silvia; Mennini, Maurizio; Piccirillo, Marisa; Ferrari, Federica; Pacchiarotti, Claudia; Ferretti, Alessandro; Fiocchi, Alessandro Giovanni; Parisi, Pasquale; Di Nardo, Giovanni. - In: NUTRITION. - ISSN 0899-9007. - 118:(2024), pp. 1-3. [10.1016/j.nut.2023.112293]
File allegati a questo prodotto
File Dimensione Formato  
Furio_FPIES-and-coeliac-disease_2024 .pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 472.14 kB
Formato Adobe PDF
472.14 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1699881
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact