The invention relates to preparation of new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer. The example compound I was prepared using f 2-phenylquinoline-4-carboxylic acid as starting material(data given).
Novel quinoline derivatives and uses thereof / Minucci, Saverio; De Wulf Peter Arthur, Irene; Romanenghi, Mauro; Cazzoli, Riccardo; Damizia, Michela; Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio. - (2022).
Novel quinoline derivatives and uses thereof
Silvestri, Romano;La Regina, Giuseppe;Coluccia, Antonio
2022
Abstract
The invention relates to preparation of new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer. The example compound I was prepared using f 2-phenylquinoline-4-carboxylic acid as starting material(data given).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
