The invention relates to preparation of new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer. The example compound I was prepared using f 2-phenylquinoline-4-carboxylic acid as starting material(data given).
Novel quinoline derivatives and uses thereof / Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio; Minucci, Saverio; De Wulf, Peter Arthur Irene. - (2021).
Novel quinoline derivatives and uses thereof
Silvestri, Romano;La Regina, Giuseppe;Coluccia, Antonio;
2021
Abstract
The invention relates to preparation of new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MT binding and of kinetochore-MT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer. The example compound I was prepared using f 2-phenylquinoline-4-carboxylic acid as starting material(data given).File allegati a questo prodotto
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