People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine should be administered over the lifetime of PLWH are questions that have become clinically relevant. Immune responses to most vaccines are known to be impaired in PLWH. Effective control of viremia with ART and restored CD4+ T-cell count are correlated with an improvement in responsiveness to routine vaccines. However, the presence of immune alterations, comorbidities and co-infections may alter it. In this article, we provide a comprehensive review of the literature on immune responses to different vaccines in the setting of HIV infection, emphasizing the potential effect of HIV-related factors and presence of comorbidities in modulating such responses. A better understanding of these issues will help guide vaccination and prevention strategies for PLWH.

Immunogenicity and efficacy of vaccination in people living with human immunodeficiency virus / Tortellini, Eeva; Fosso Ngangue, Yann Collins; Dominelli, Federica; Guardiani, Mariasilvia; Falvino, Carmen; Mengoni, Fabio; Carraro, Anna; Marocco, Raffaella; Pasculli, Patrizia; Mastroianni, Claudio Maria; Ciardi, Maria Rosa; Lichtner, Miriam; Zingaropoli, Maria Antonella. - In: VIRUSES. - ISSN 1999-4915. - 15:9(2023), pp. 1-23. [10.3390/v15091844]

Immunogenicity and efficacy of vaccination in people living with human immunodeficiency virus

Tortellini, Eeva
;
Fosso Ngangue, Yann Collins;Dominelli, Federica;Guardiani, Mariasilvia;Falvino, Carmen;Mengoni, Fabio;Carraro, Anna;Marocco, Raffaella;Pasculli, Patrizia;Mastroianni, Claudio Maria;Ciardi, Maria Rosa;Lichtner, Miriam;Zingaropoli, Maria Antonella
2023

Abstract

People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine should be administered over the lifetime of PLWH are questions that have become clinically relevant. Immune responses to most vaccines are known to be impaired in PLWH. Effective control of viremia with ART and restored CD4+ T-cell count are correlated with an improvement in responsiveness to routine vaccines. However, the presence of immune alterations, comorbidities and co-infections may alter it. In this article, we provide a comprehensive review of the literature on immune responses to different vaccines in the setting of HIV infection, emphasizing the potential effect of HIV-related factors and presence of comorbidities in modulating such responses. A better understanding of these issues will help guide vaccination and prevention strategies for PLWH.
2023
art; cd4; covid-19; hiv; hpv; plwh; immune responses; influenza; vaccination
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Immunogenicity and efficacy of vaccination in people living with human immunodeficiency virus / Tortellini, Eeva; Fosso Ngangue, Yann Collins; Dominelli, Federica; Guardiani, Mariasilvia; Falvino, Carmen; Mengoni, Fabio; Carraro, Anna; Marocco, Raffaella; Pasculli, Patrizia; Mastroianni, Claudio Maria; Ciardi, Maria Rosa; Lichtner, Miriam; Zingaropoli, Maria Antonella. - In: VIRUSES. - ISSN 1999-4915. - 15:9(2023), pp. 1-23. [10.3390/v15091844]
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Note: Immunogenicity and Efficacy of Vaccination in People Living with Human Immunodeficiency Virus
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1690446
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