Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.

Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease / Babiloni, Claudio; Lopez, Susanna; Noce, Giuseppe; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; Salvatore, Marco; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Massa, Federico; Buttinelli, Carla; Giubilei, Franco; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; D'Antonio, Fabrizia; Bruno, Giuseppe; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Yerlikaya, Deniz; Taylor, John Paul; Schumacher, Julia; Mckeith, Ian; Bonanni, Laura; Pantano, Patrizia; Piervincenzi, Claudia; Petsas, Nikolaos; Frisoni, Giovanni B; Del Percio, Claudio; Carducci, Filippo. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - (2023). [10.1093/cercor/bhad300]

Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease

Babiloni, Claudio
Co-primo
Supervision
;
Lopez, Susanna
Co-primo
Formal Analysis
;
Noce, Giuseppe;Buttinelli, Carla
Membro del Collaboration Group
;
Giubilei, Franco
Membro del Collaboration Group
;
Stocchi, Fabrizio
Membro del Collaboration Group
;
D'Antonio, Fabrizia
Membro del Collaboration Group
;
De Lena, Carlo
Membro del Collaboration Group
;
Pantano, Patrizia
Membro del Collaboration Group
;
Piervincenzi, Claudia
Membro del Collaboration Group
;
Petsas, Nikolaos
Membro del Collaboration Group
;
Del Percio, Claudio
Membro del Collaboration Group
;
Carducci, Filippo
Ultimo
Project Administration
2023

Abstract

Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.
2023
Alzheimer’s disease with dementia (ADD); Default mode network (DMN); Exact low-resolution brain electromagnetic source tomography (eLORETA); Resting state electroencephalographic (rsEEG) alpha rhythms; Structural magnetic resonance imaging (sMRI)
01 Pubblicazione su rivista::01a Articolo in rivista
Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease / Babiloni, Claudio; Lopez, Susanna; Noce, Giuseppe; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; Salvatore, Marco; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Massa, Federico; Buttinelli, Carla; Giubilei, Franco; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; D'Antonio, Fabrizia; Bruno, Giuseppe; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Yerlikaya, Deniz; Taylor, John Paul; Schumacher, Julia; Mckeith, Ian; Bonanni, Laura; Pantano, Patrizia; Piervincenzi, Claudia; Petsas, Nikolaos; Frisoni, Giovanni B; Del Percio, Claudio; Carducci, Filippo. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - (2023). [10.1093/cercor/bhad300]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1689598
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