Abstract: Cow’s milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or “dysbiosis”. Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics’ efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.

Molecular mechanism and clinical effects of probiotics in the management of cow’s milk protein allergy / Cela, Ludovica; Brindisi, Giulia; Gravina, Alessandro; Pastore, Francesca; Semeraro, Antonio; Bringheli, Ivana; Marchetti, Lavinia; Morelli, Rebecca; Cinicola, Bianca; Capponi, Martina; Gori, Alessandra; Pignataro, Elia; Piccioni, Maria Grazia; Zicari, Anna Maria; Anania, Caterina. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:12(2023). [10.3390/ijms24129781]

Molecular mechanism and clinical effects of probiotics in the management of cow’s milk protein allergy

Ludovica Cela;Giulia Brindisi;Alessandro Gravina;Antonio Semeraro;Ivana Bringheli;Lavinia Marchetti;Rebecca Morelli;Bianca Cinicola;Elia Pignataro;Maria Grazia Piccioni;Anna Maria Zicari;Caterina Anania
2023

Abstract

Abstract: Cow’s milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or “dysbiosis”. Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics’ efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.
2023
children; cow’s milk protein allergy (cmpa); microbiota; pediatric; probiotics
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Molecular mechanism and clinical effects of probiotics in the management of cow’s milk protein allergy / Cela, Ludovica; Brindisi, Giulia; Gravina, Alessandro; Pastore, Francesca; Semeraro, Antonio; Bringheli, Ivana; Marchetti, Lavinia; Morelli, Rebecca; Cinicola, Bianca; Capponi, Martina; Gori, Alessandra; Pignataro, Elia; Piccioni, Maria Grazia; Zicari, Anna Maria; Anania, Caterina. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24:12(2023). [10.3390/ijms24129781]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1685082
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