Fetal alcohol spectrum disorder (FASD) is a set of conditions resulting from prenatal alcohol exposure (PAE). FASD is estimated to affect between 2% and 5% of people in the United States and Western Europe. The exact teratogenic mechanism of alcohol on fetal development is still unclear. Ethanol (EtOH) contributes to the malfunctioning of the neurological system in children exposed in utero by decreasing glutathione peroxidase action, with an increase in the production of reactive oxygen species (ROS), which causes oxidative stress. We report a case of a mother with declared alcohol abuse and cigarette smoking during pregnancy. By analyzing the ethyl glucuronide (EtG, a metabolite of alcohol) and the nicotine/cotinine in the mother’s hair and meconium, we confirmed the alcohol and smoking abuse magnitude. We also found that the mother during pregnancy was a cocaine abuser. As a result, her newborn was diagnosed with fetal alcohol syndrome (FAS). At the time of the delivery, the mother, but not the newborn, had an elevation in oxidative stress. However, the infant, a few days later, displayed marked potentiation in oxidative stress. The clinical complexity of the events involving the infant was presented and discussed, underlining also the importance that for cases of FASD, it is crucial to have more intensive hospital monitoring and controls during the initial days.

Oxidative stress in a mother consuming alcohol during pregnancy and in her newborn. a case report / Derme, Martina; Piccioni, Maria Grazia; Brunelli, Roberto; Crognale, Alba; Denotti, Marika; Ciolli, Paola; Scomparin, Debora; Tarani, Luigi; Paparella, Roberto; Terrin, Gianluca; DI CHIARA, Maria; Mattia, Alessandro; Nicotera, Simona; Salomone, Alberto; Ceccanti, Mauro; Messina, Marisa Patrizia; LA MAIDA, Nunzia; Ferraguti, Giampiero; Petrella, Carla; Fiore, Marco. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 12:6(2023), pp. 1-11. [10.3390/antiox12061216]

Oxidative stress in a mother consuming alcohol during pregnancy and in her newborn. a case report

Martina Derme;Maria Grazia Piccioni;Roberto Brunelli;Alba Crognale;Marika Denotti;Paola Ciolli;Luigi Tarani;Roberto Paparella;Gianluca Terrin;Maria Di Chiara;Mauro Ceccanti;Marisa Patrizia Messina;Nunzia La Maida;Giampiero Ferraguti;Carla Petrella;
2023

Abstract

Fetal alcohol spectrum disorder (FASD) is a set of conditions resulting from prenatal alcohol exposure (PAE). FASD is estimated to affect between 2% and 5% of people in the United States and Western Europe. The exact teratogenic mechanism of alcohol on fetal development is still unclear. Ethanol (EtOH) contributes to the malfunctioning of the neurological system in children exposed in utero by decreasing glutathione peroxidase action, with an increase in the production of reactive oxygen species (ROS), which causes oxidative stress. We report a case of a mother with declared alcohol abuse and cigarette smoking during pregnancy. By analyzing the ethyl glucuronide (EtG, a metabolite of alcohol) and the nicotine/cotinine in the mother’s hair and meconium, we confirmed the alcohol and smoking abuse magnitude. We also found that the mother during pregnancy was a cocaine abuser. As a result, her newborn was diagnosed with fetal alcohol syndrome (FAS). At the time of the delivery, the mother, but not the newborn, had an elevation in oxidative stress. However, the infant, a few days later, displayed marked potentiation in oxidative stress. The clinical complexity of the events involving the infant was presented and discussed, underlining also the importance that for cases of FASD, it is crucial to have more intensive hospital monitoring and controls during the initial days.
2023
fetal alcohol spectrum disorder (fasd); prenatal alcohol exposure (pae); oxidative stress; ethyl glucuronide
01 Pubblicazione su rivista::01i Case report
Oxidative stress in a mother consuming alcohol during pregnancy and in her newborn. a case report / Derme, Martina; Piccioni, Maria Grazia; Brunelli, Roberto; Crognale, Alba; Denotti, Marika; Ciolli, Paola; Scomparin, Debora; Tarani, Luigi; Paparella, Roberto; Terrin, Gianluca; DI CHIARA, Maria; Mattia, Alessandro; Nicotera, Simona; Salomone, Alberto; Ceccanti, Mauro; Messina, Marisa Patrizia; LA MAIDA, Nunzia; Ferraguti, Giampiero; Petrella, Carla; Fiore, Marco. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 12:6(2023), pp. 1-11. [10.3390/antiox12061216]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1684346
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