Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis / Anastasi, Emanuela; Farina, Antonella; Granato, Teresa; Colaiacovo, Flavia; Pucci, Beatrice; Tartaglione, Sara; Angeloni, Antonio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24(13):(2023). [10.3390/ijms241310479]

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Emanuela Anastasi
Primo
Writing – Review & Editing
;
Antonella Farina
Secondo
Writing – Review & Editing
;
Flavia Colaiacovo
Resources
;
Beatrice Pucci
Data Curation
;
Sara Tartaglione
Writing – Review & Editing
;
Antonio Angeloni
Supervision
2023

Abstract

Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.
2023
ovarian cancer; HE4; oncogenesis; target therapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis / Anastasi, Emanuela; Farina, Antonella; Granato, Teresa; Colaiacovo, Flavia; Pucci, Beatrice; Tartaglione, Sara; Angeloni, Antonio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 24(13):(2023). [10.3390/ijms241310479]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1684344
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