Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that occurs worldwide. Despite some progress in understanding the onset of HD, drugs that block or delay symptoms are still not available. In recent years, many treatments have been proposed; among them, nuclear transcriptional factor-2 (Nrf2) enhancer compounds have been proposed as potential therapeutic agents to treat HD. Nrf2 triggers an endogenous antioxidant pathway activated in different neurodegenerative disorders. Probably, the stimulation of Nrf2 during either the early phase or before HD symptoms' onset, could slow or prevent striatum degeneration. In this review, we present the scientific literature supporting the role of Nrf2 in HD and the potential prophylactic and therapeutic role of this compound.

Nrf2 pathway in Huntington's disease (hd): What is its role? / Tucci, Paolo; Lattanzi, Roberta; Severini, Cinzia; Saso, Luciano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:23(2022), pp. 1-17. [10.3390/ijms232315272]

Nrf2 pathway in Huntington's disease (hd): What is its role?

Tucci, Paolo;Lattanzi, Roberta;Saso, Luciano
2022

Abstract

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that occurs worldwide. Despite some progress in understanding the onset of HD, drugs that block or delay symptoms are still not available. In recent years, many treatments have been proposed; among them, nuclear transcriptional factor-2 (Nrf2) enhancer compounds have been proposed as potential therapeutic agents to treat HD. Nrf2 triggers an endogenous antioxidant pathway activated in different neurodegenerative disorders. Probably, the stimulation of Nrf2 during either the early phase or before HD symptoms' onset, could slow or prevent striatum degeneration. In this review, we present the scientific literature supporting the role of Nrf2 in HD and the potential prophylactic and therapeutic role of this compound.
2022
huntington’s disease; nrf2; antioxidant; neurodegenerative disease; oxidative stress
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Nrf2 pathway in Huntington's disease (hd): What is its role? / Tucci, Paolo; Lattanzi, Roberta; Severini, Cinzia; Saso, Luciano. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:23(2022), pp. 1-17. [10.3390/ijms232315272]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1681527
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