bstance P (SP) and its cognate Neurokinin receptor 1 (NK1R) are tachykinergic neuroinflammatory mediators widely expressed in the central nervous system, peripheral nervous system, enteric nervous system, and immune cells. The SP/NK1R pathway is activated by several noxious stimuli and triggers a sustained inflammatory response by inducing cytokines release from different cell subtypes. In Parkinson's disease (PD), SP colocalizes with α-synuclein in the central and peripheral structures more prone to degeneration, mostly within the gastrointestinal–nervous ascending system, suggesting a potential role in the disease pathogenesis through inflammation-related mechanisms.
Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction / Schirinzi, T., Maftei, D., Grillo, P., Bovenzi, R., Bissacco, J., Simonetta, C., Mascioli, D., Zenuni, H., Cerroni, R., Vincenzi, M., Maurizi, R., Passali, F.M., Di Girolamo, S., Ralli, M., Magliulo, G., Tirassa, P., Stefani, A., Mercuri, N.B., Lattanzi, R., Severini, C.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - (2023). [10.1002/mds.29433]
Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction
Maftei, DanielaSecondo
;Grillo, Piergiorgio;Mascioli, Davide;Vincenzi, Martina;Maurizi, Riccardo;Ralli, Massimo;Magliulo, Giuseppe;Stefani, Alessandro;Lattanzi, RobertaPenultimo
;
2023
Abstract
bstance P (SP) and its cognate Neurokinin receptor 1 (NK1R) are tachykinergic neuroinflammatory mediators widely expressed in the central nervous system, peripheral nervous system, enteric nervous system, and immune cells. The SP/NK1R pathway is activated by several noxious stimuli and triggers a sustained inflammatory response by inducing cytokines release from different cell subtypes. In Parkinson's disease (PD), SP colocalizes with α-synuclein in the central and peripheral structures more prone to degeneration, mostly within the gastrointestinal–nervous ascending system, suggesting a potential role in the disease pathogenesis through inflammation-related mechanisms.| File | Dimensione | Formato | |
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