Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates. The usefulness of vagus nerve-stimulation (VNS) implantation during RSE has been documented by anecdotal cases and in systematic reviews; however, the use of VNS in RSE has not been widely adopted. We successfully implanted VNS in two patients with genetic epilepsy admitted to hospital for SRSE; detailed descriptions of the clinical findings and VNS parameters are provided. Our patients were implanted 25 and 58 days after status epilepticus (SE) onset, and a stable remission of SE was observed from the seventh and tenth day after VNS implantation, respectively, without change in anti-seizure medication. We used a fast ramp-up of stimulation without evident side effects. Our results support the consideration of VNS implantation as a safe and effective adjunctive treatment for SRSE.

Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option? / Specchio, Nicola; Ferretti, Alessandro; Pietrafusa, Nicola; Trivisano, Marina; Calabrese, Costanza; Carfì Pavia, Giusy; De Benedictis, Alessandro; Marras, Carlo Efisio; de Palma, Luca; Vigevano, Federico. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - 11:(2020), pp. 1-5. [10.3389/fneur.2020.00443]

Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option?

Ferretti, Alessandro
Secondo
;
de Palma, Luca;
2020

Abstract

Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates. The usefulness of vagus nerve-stimulation (VNS) implantation during RSE has been documented by anecdotal cases and in systematic reviews; however, the use of VNS in RSE has not been widely adopted. We successfully implanted VNS in two patients with genetic epilepsy admitted to hospital for SRSE; detailed descriptions of the clinical findings and VNS parameters are provided. Our patients were implanted 25 and 58 days after status epilepticus (SE) onset, and a stable remission of SE was observed from the seventh and tenth day after VNS implantation, respectively, without change in anti-seizure medication. We used a fast ramp-up of stimulation without evident side effects. Our results support the consideration of VNS implantation as a safe and effective adjunctive treatment for SRSE.
2020
epilepsy; genetic epilepsies; status epilepticus; treatment; vagal nerve stimulation (vns)
01 Pubblicazione su rivista::01i Case report
Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option? / Specchio, Nicola; Ferretti, Alessandro; Pietrafusa, Nicola; Trivisano, Marina; Calabrese, Costanza; Carfì Pavia, Giusy; De Benedictis, Alessandro; Marras, Carlo Efisio; de Palma, Luca; Vigevano, Federico. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - 11:(2020), pp. 1-5. [10.3389/fneur.2020.00443]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1677837
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