Benzo[a]pyrene (BaP) is a well-known polycyclic aromatic hydrocarbon, generated by the incomplete combustion of organic compounds. BaP, which exerts its genotoxic effects after metabolic activation by cytochrome P450s, can induce DNA damage through the formation of adducts or by inducing oxidative stress. Although BaP is currently one of the most studied pollutants, to date the toxicogenomic effect of BaP in the adult human testis has never been studied. The aim of this study is to evaluate the direct effect of this pollutant on human testis using an organotypic culture in vitro model.
Effects of Benzo[a]pyrene in human testicular organotypic culture / Tartarelli, Irene; Sperduti, Samantha; Capponi, Chiara; Fera, Stefania; Pozza, Carlotta; Isidori, Andrea; Simoni, Manuela; Casarini, Livio; Vicini, Elena.. - (2021). (Intervento presentato al convegno SIAMS 2021 tenutosi a Bologna).
Effects of Benzo[a]pyrene in human testicular organotypic culture.
Tartarelli Irene;Capponi Chiara;Stefania Fera;Pozza Carlotta;Isidori Andrea;Vicini Elena.
2021
Abstract
Benzo[a]pyrene (BaP) is a well-known polycyclic aromatic hydrocarbon, generated by the incomplete combustion of organic compounds. BaP, which exerts its genotoxic effects after metabolic activation by cytochrome P450s, can induce DNA damage through the formation of adducts or by inducing oxidative stress. Although BaP is currently one of the most studied pollutants, to date the toxicogenomic effect of BaP in the adult human testis has never been studied. The aim of this study is to evaluate the direct effect of this pollutant on human testis using an organotypic culture in vitro model.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
