Human and non-human primate spermatogonia (SPG) share important similarities [1]. Recently, a new classification was proposed for the human SPG compartment based on protein markers such as, MAGEA4, GFRA1, KIT, etc. [2]. Even though, the kinetic of monkey SPG has been previously investigated [3], less is known about the expression profile of spermatogonial markers. Here we tested the hypothesis that SPG marker expression and progression in human and non-human primates is conserved. To this end, we analyzed the expression of human markers, in Macaca fascicularis SPG and their proliferation activity during the stages of the seminiferous epithelium cycle [4, 5].
Analysis of spermatogonial marker expression in non-human primate / Capponi, Chiara; DI PERSIO, Sara; Fera, Stefania; Schlatt, Stefan; Neuhaus, Nina; DE ROOIJ, DIRK GIJSBERT; Vicini, Elena. - (2021). (Intervento presentato al convegno 21st European Testis Workshop tenutosi a online).
Analysis of spermatogonial marker expression in non-human primate
Capponi Chiara;Di Persio Sara;Fera Stefania;de Rooij Dirk;Vicini Elena
2021
Abstract
Human and non-human primate spermatogonia (SPG) share important similarities [1]. Recently, a new classification was proposed for the human SPG compartment based on protein markers such as, MAGEA4, GFRA1, KIT, etc. [2]. Even though, the kinetic of monkey SPG has been previously investigated [3], less is known about the expression profile of spermatogonial markers. Here we tested the hypothesis that SPG marker expression and progression in human and non-human primates is conserved. To this end, we analyzed the expression of human markers, in Macaca fascicularis SPG and their proliferation activity during the stages of the seminiferous epithelium cycle [4, 5].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
