Follicular dendritic cell (FDC) proliferation in angioimmunoblastic T-cell lymphoma (AITL) is still not well defined, challenging the accurate differential diagnosis between the AITL with expanded follicular dendritic cell meshwork and the combined AITL and follicular dendritic cell sarcoma (FDCS). Herein, we reported the case of a 58-year-old male with coexisting SARS-CoV-2 infection and AITL with an exuberant CD30-positive FDC proliferation, in which genetic analysis identified mutations of genes commonly involved in AITL but not in FDC sarcoma (i.e., RHOA, TET2, DNMT3A, and IDH2), thus supporting the reactive nature of the CD30-positive FDC expansion.

Angioimmunoblastic T-Cell Lymphoma with Exuberant CD30-Positive Follicular Dendritic Cell Proliferation in a SARS-CoV-2 Patient. The Role of Mutational Analysis to Exclude an Associated Follicular Dendritic Cell Sarcoma / Rogges, Evelina; Pelliccia, Sabrina; Lopez, Gianluca; Barresi, Sabina; Tafuri, Agostino; Alaggio, Rita; Di Napoli, Arianna. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:16(2022), pp. 1-8. [10.3390/ijms23169349]

Angioimmunoblastic T-Cell Lymphoma with Exuberant CD30-Positive Follicular Dendritic Cell Proliferation in a SARS-CoV-2 Patient. The Role of Mutational Analysis to Exclude an Associated Follicular Dendritic Cell Sarcoma

Rogges, Evelina;Pelliccia, Sabrina;Lopez, Gianluca;Tafuri, Agostino;Alaggio, Rita;Di Napoli, Arianna
2022

Abstract

Follicular dendritic cell (FDC) proliferation in angioimmunoblastic T-cell lymphoma (AITL) is still not well defined, challenging the accurate differential diagnosis between the AITL with expanded follicular dendritic cell meshwork and the combined AITL and follicular dendritic cell sarcoma (FDCS). Herein, we reported the case of a 58-year-old male with coexisting SARS-CoV-2 infection and AITL with an exuberant CD30-positive FDC proliferation, in which genetic analysis identified mutations of genes commonly involved in AITL but not in FDC sarcoma (i.e., RHOA, TET2, DNMT3A, and IDH2), thus supporting the reactive nature of the CD30-positive FDC expansion.
2022
aitl; cd30 expression; sars-cov-2 infection; follicular dendritic cell proliferation
01 Pubblicazione su rivista::01i Case report
Angioimmunoblastic T-Cell Lymphoma with Exuberant CD30-Positive Follicular Dendritic Cell Proliferation in a SARS-CoV-2 Patient. The Role of Mutational Analysis to Exclude an Associated Follicular Dendritic Cell Sarcoma / Rogges, Evelina; Pelliccia, Sabrina; Lopez, Gianluca; Barresi, Sabina; Tafuri, Agostino; Alaggio, Rita; Di Napoli, Arianna. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:16(2022), pp. 1-8. [10.3390/ijms23169349]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1674322
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