Endometrial cancer (EC) is one of the most common gynecological malignancies in Western countries. Traditionally, loco-reginal dissemination and histological characteristics are the main prognostic factors. Nowadays, molecular and genomic profiling showed exciting results in terms of prognostication. According to the data provided by The Cancer Genome Atlas and other studies, molecular and genomic profiling might be useful in identifying patients al low, intermediate, and high risk of recurrence. However, data regarding the therapeutic value are scant. Several prospective studies are ongoing to identify the most appropriate adjuvant strategy in EC patients, especially for those with positive nodes and low volume disease. The molecular classification has offered the possibility to improve the risk stratification and management of EC. The aim of this review is to focus on the evolution of molecular classification in EC and its impact on the research approach and on clinical management. Molecular and genomic profiling might be useful to tailor the most appropriate adjuvant strategies in apparent early-stage EC.

Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer. narrative review and perspectives / Cuccu, Ilaria; D'Oria, Ottavia; Sgamba, Ludovica; De Angelis, Emanuele; D'Augè Tullio, Golia; Turetta, Camilla; DI DIO, Camilla; Scudo, Maria; Bogani, Giorgio; DI DONATO, Violante; Palaia, Innocenza; Perniola, Giorgia; Tomao, Federica; Muzii, Ludovico; Giannini, Andrea. - In: HEALTHCARE. - ISSN 2227-9032. - 11:4(2023), pp. 1-12. [10.3390/healthcare11040571]

Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer. narrative review and perspectives

Ilaria Cuccu;Ottavia D'Oria
;
Ludovica Sgamba;Emanuele De Angelis;Camilla Turetta;Camilla Di Dio;Maria Scudo;Giorgio Bogani;Violante Di Donato;Innocenza Palaia;Giorgia Perniola;Federica Tomao;Ludovico Muzii;Andrea Giannini
2023

Abstract

Endometrial cancer (EC) is one of the most common gynecological malignancies in Western countries. Traditionally, loco-reginal dissemination and histological characteristics are the main prognostic factors. Nowadays, molecular and genomic profiling showed exciting results in terms of prognostication. According to the data provided by The Cancer Genome Atlas and other studies, molecular and genomic profiling might be useful in identifying patients al low, intermediate, and high risk of recurrence. However, data regarding the therapeutic value are scant. Several prospective studies are ongoing to identify the most appropriate adjuvant strategy in EC patients, especially for those with positive nodes and low volume disease. The molecular classification has offered the possibility to improve the risk stratification and management of EC. The aim of this review is to focus on the evolution of molecular classification in EC and its impact on the research approach and on clinical management. Molecular and genomic profiling might be useful to tailor the most appropriate adjuvant strategies in apparent early-stage EC.
2023
endometrial cancer; genetics; molecular; personalized treatment; target therapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer. narrative review and perspectives / Cuccu, Ilaria; D'Oria, Ottavia; Sgamba, Ludovica; De Angelis, Emanuele; D'Augè Tullio, Golia; Turetta, Camilla; DI DIO, Camilla; Scudo, Maria; Bogani, Giorgio; DI DONATO, Violante; Palaia, Innocenza; Perniola, Giorgia; Tomao, Federica; Muzii, Ludovico; Giannini, Andrea. - In: HEALTHCARE. - ISSN 2227-9032. - 11:4(2023), pp. 1-12. [10.3390/healthcare11040571]
File allegati a questo prodotto
File Dimensione Formato  
Cuccu_Role-genomic-molecular_2023.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 290.06 kB
Formato Adobe PDF
290.06 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1672844
Citazioni
  • ???jsp.display-item.citation.pmc??? 29
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 42
social impact