In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients' quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy.
Protective Role of Natural Compounds under Radiation-Induced Injury / Altomare, Annamaria; Fiore, Michele; D'Ercole, Gabriele; Imperia, Elena; Nicolosi, Roberta Maria; Della Posta, Susanna; Pasqua, Gabriella; Cicala, Michele; De Gara, Laura; Ramella, Sara; Guarino, Michele Pier Luca. - In: NUTRIENTS. - ISSN 2072-6643. - 14:24(2022), p. 5374. [10.3390/nu14245374]
Protective Role of Natural Compounds under Radiation-Induced Injury
D'Ercole, Gabriele;Nicolosi, Roberta Maria;Pasqua, Gabriella;
2022
Abstract
In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients' quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
