The positive charge on liposome surface is known to promote the crossing of the Blood brain barrier (BBB). However, when diastereomeric cationic gemini amphiphiles are among lipid membrane components, also the stereochemistry may affect the permeability of the vesicle across the BBB.
Transport of cationic liposomes in a human blood brain barrier model: role of the stereochemistry of the gemini amphiphile on liposome biological features / Simonis, Beatrice; Vignone, Domenico; Gonzalez Paz, Odalys; Donati, Enrica; Falchetti, Maria Laura; Bombelli, Cecilia; Cellucci, Antonella; Auciello, Giulio; Fini, Ivan; Galantini, Luciano; Syeda, Rudaba Zaman; Mazzonna, Marco; Mongiardi, Maria Patrizia; Buonocore, Francesco; Ceccacci, Francesca; Di Marco, Annalise; Mancini, Giovanna. - In: JOURNAL OF COLLOID AND INTERFACE SCIENCE. - ISSN 1095-7103. - 627:(2022), pp. 283-298. [10.1016/j.jcis.2022.07.025]
Transport of cationic liposomes in a human blood brain barrier model: role of the stereochemistry of the gemini amphiphile on liposome biological features
Simonis, Beatrice;Vignone, Domenico;Donati, Enrica;Bombelli, Cecilia;Cellucci, Antonella;Galantini, Luciano;Mazzonna, Marco;Ceccacci, Francesca;
2022
Abstract
The positive charge on liposome surface is known to promote the crossing of the Blood brain barrier (BBB). However, when diastereomeric cationic gemini amphiphiles are among lipid membrane components, also the stereochemistry may affect the permeability of the vesicle across the BBB.| File | Dimensione | Formato | |
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