Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated. Across the United States, SCD cases in those less than 40 years of age will often fall under medical examiner/coroner jurisdiction resulting in scene investigation, review of available medical records and a complete autopsy including toxicological and histological studies. To date, there have not been consistent or uniform guidelines for cardiac examination in these cases. In addition, many medical examiner/coroner offices are understaffed and/or underfunded, both of which may hamper specialized examinations or studies (eg. molecular testing). Use of such guidelines by pathologists in cases of SCD in decedents aged 1 to 39 years of age could result in life-saving medical intervention for other family members. These recommendations also may provide support for underfunded offices to argue for the significance of this specialized testing. As cardiac examinations in the setting of SCD in the young fall under ME/C jurisdiction, this consensus paper has been developed with members of the Society of Cardiovascular Pathology working with cardiovascular pathology-trained, practicing forensic pathologists.

Sudden cardiac death in the young: a consensus statement on recommended practices for cardiac examination by the pathologist from the Society for Cardiovascular Pathology / Kelly, Karen L; Lin, Peter T; Basso, Cristina; Bois, Melanie; Buja, L Maximilian; Cohle, Stephen D; D'Amati, Giulia; Duncanson, Emily; Fallon, John T; Firchau, Dennis; Fishbein, Gregory; Giordano, Carla; Leduc, Charles; Litovsky, Silvio H; Mackey-Bojack, Shannon; Maleszewski, Joseph J; Michaud, Katarzyna; Padera, Robert F; Papadodima, Stavroula A; Parsons, Sarah; Radio, Stanley J; Rizzo, Stefania; Roe, Susan J; Romero, Maria; Sheppard, Mary N; Stone, James R; Tan, Carmela D; Thiene, Gaetano; van der Wal, Allard C; Veinot, John P. - In: CARDIOVASCULAR PATHOLOGY. - ISSN 1054-8807. - 63:(2022). [10.1016/j.carpath.2022.107497]

Sudden cardiac death in the young: a consensus statement on recommended practices for cardiac examination by the pathologist from the Society for Cardiovascular Pathology

d'Amati, Giulia
Membro del Collaboration Group
;
Giordano, Carla
Membro del Collaboration Group
;
Thiene, Gaetano;
2022

Abstract

Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated. Across the United States, SCD cases in those less than 40 years of age will often fall under medical examiner/coroner jurisdiction resulting in scene investigation, review of available medical records and a complete autopsy including toxicological and histological studies. To date, there have not been consistent or uniform guidelines for cardiac examination in these cases. In addition, many medical examiner/coroner offices are understaffed and/or underfunded, both of which may hamper specialized examinations or studies (eg. molecular testing). Use of such guidelines by pathologists in cases of SCD in decedents aged 1 to 39 years of age could result in life-saving medical intervention for other family members. These recommendations also may provide support for underfunded offices to argue for the significance of this specialized testing. As cardiac examinations in the setting of SCD in the young fall under ME/C jurisdiction, this consensus paper has been developed with members of the Society of Cardiovascular Pathology working with cardiovascular pathology-trained, practicing forensic pathologists.
2022
sudden cardiac death; sudden death; death in the young; forensic pathology heart examination; hypertrophic cardiomyopathy; genomics of sudden death; cardiomyopathy; sudden unexpected death in epilepsy
01 Pubblicazione su rivista::01a Articolo in rivista
Sudden cardiac death in the young: a consensus statement on recommended practices for cardiac examination by the pathologist from the Society for Cardiovascular Pathology / Kelly, Karen L; Lin, Peter T; Basso, Cristina; Bois, Melanie; Buja, L Maximilian; Cohle, Stephen D; D'Amati, Giulia; Duncanson, Emily; Fallon, John T; Firchau, Dennis; Fishbein, Gregory; Giordano, Carla; Leduc, Charles; Litovsky, Silvio H; Mackey-Bojack, Shannon; Maleszewski, Joseph J; Michaud, Katarzyna; Padera, Robert F; Papadodima, Stavroula A; Parsons, Sarah; Radio, Stanley J; Rizzo, Stefania; Roe, Susan J; Romero, Maria; Sheppard, Mary N; Stone, James R; Tan, Carmela D; Thiene, Gaetano; van der Wal, Allard C; Veinot, John P. - In: CARDIOVASCULAR PATHOLOGY. - ISSN 1054-8807. - 63:(2022). [10.1016/j.carpath.2022.107497]
File allegati a questo prodotto
File Dimensione Formato  
Kelly_Sudden-cardiac_2022.pdf

Open Access dal 13/11/2023

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 1.13 MB
Formato Adobe PDF
1.13 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1660801
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 13
social impact