The presence of anti-IFN neutralizing antibodies (NAB) has been reported in critically ill COVID-19 patients. We found that 87.5% (7/8) of HIV-1 patients co-infected with SARS-CoV-2 had serum anti-IFN-I NAB against IFN-alpha subtypes, IFN-beta and/or IFN-omega. Anti-IFN-I NAB were also detected in oropharyngeal samples. Patients with NAB were males, and those with high serum anti-IFN-alpha/omega NAB titer had severe illness and exhibited reduction in the expression of IFN-stimulated genes. Thus, high titer of anti-IFN-alpha/omega NAB may contribute to the greater severity of COVID-19 in HIV-1 infected patients.
High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19 / Scordio, Mirko; Frasca, Federica; Santinelli, Letizia; Sorrentino, Leonardo; Pierangeli, Alessandra; Turriziani, Ombretta; Mastroianni, Claudio M; Antonelli, Guido; Viscidi, Raphael P; D'Ettorre, Gabriella; Scagnolari, Carolina. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 241:(2022), pp. 1-4. [10.1016/j.clim.2022.109068]
High frequency of neutralizing antibodies to type I Interferon in HIV-1 patients hospitalized for COVID-19
Scordio, Mirko;Frasca, Federica;Santinelli, Letizia;Sorrentino, Leonardo;Pierangeli, Alessandra;Turriziani, Ombretta;Mastroianni, Claudio M;Antonelli, Guido;d'Ettorre, Gabriella;Scagnolari, Carolina
2022
Abstract
The presence of anti-IFN neutralizing antibodies (NAB) has been reported in critically ill COVID-19 patients. We found that 87.5% (7/8) of HIV-1 patients co-infected with SARS-CoV-2 had serum anti-IFN-I NAB against IFN-alpha subtypes, IFN-beta and/or IFN-omega. Anti-IFN-I NAB were also detected in oropharyngeal samples. Patients with NAB were males, and those with high serum anti-IFN-alpha/omega NAB titer had severe illness and exhibited reduction in the expression of IFN-stimulated genes. Thus, high titer of anti-IFN-alpha/omega NAB may contribute to the greater severity of COVID-19 in HIV-1 infected patients.| File | Dimensione | Formato | |
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