Topological transitions of fluid lipid membranes are fundamental processes for cell life. For example, they are required for endo- and exocytosis or to enable neurotransmitters to cross the neural synapses. Here, inspired by the idea that fusion and fission proteins could have evolved in Nature in order to carry out a minimal work expenditure, we evaluate the minimal free energy pathway for the transition between two spherical large unilamellar vesicles and a dumbbell-shaped one. To address the problem, we propose and successfully use a Ginzburg-Landau type of free energy, which allows us to uniquely describe without interruption the whole, full-scale topological change. We also compute the force fields needed to overcome the involved energy barriers. The obtained forces are in excellent agreement, in terms of intensity, scale, and spatial localization with experimental data on typical fission protein systems, whereas they suggest the presence of additional features in fusion proteins.

Activation energy and force fields during topological transitions of fluid lipid vesicles / Bottacchiari, Matteo; Gallo, Mirko; Bussoletti, Marco; Casciola, Carlo Massimo. - In: COMMUNICATIONS PHYSICS. - ISSN 2399-3650. - 5:1(2022). [10.1038/s42005-022-01055-2]

Activation energy and force fields during topological transitions of fluid lipid vesicles

Bottacchiari, Matteo;Gallo, Mirko;Bussoletti, Marco;Casciola, Carlo Massimo
2022

Abstract

Topological transitions of fluid lipid membranes are fundamental processes for cell life. For example, they are required for endo- and exocytosis or to enable neurotransmitters to cross the neural synapses. Here, inspired by the idea that fusion and fission proteins could have evolved in Nature in order to carry out a minimal work expenditure, we evaluate the minimal free energy pathway for the transition between two spherical large unilamellar vesicles and a dumbbell-shaped one. To address the problem, we propose and successfully use a Ginzburg-Landau type of free energy, which allows us to uniquely describe without interruption the whole, full-scale topological change. We also compute the force fields needed to overcome the involved energy barriers. The obtained forces are in excellent agreement, in terms of intensity, scale, and spatial localization with experimental data on typical fission protein systems, whereas they suggest the presence of additional features in fusion proteins.
2022
fluid lipid vesicle; topological transitions; gauss-bonnet; fusion; fission; helfrich; gaussian energy
01 Pubblicazione su rivista::01a Articolo in rivista
Activation energy and force fields during topological transitions of fluid lipid vesicles / Bottacchiari, Matteo; Gallo, Mirko; Bussoletti, Marco; Casciola, Carlo Massimo. - In: COMMUNICATIONS PHYSICS. - ISSN 2399-3650. - 5:1(2022). [10.1038/s42005-022-01055-2]
File allegati a questo prodotto
File Dimensione Formato  
Bottacchiari_activation-energy_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.21 MB
Formato Adobe PDF
2.21 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1659087
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 4
social impact