Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has affected millions of people around the world in the last years. Among susceptible patients, pregnant women seem to be prone to have serious complications. The possibility of SARS-CoV-2 vertical transmission represents one of the most debated topics in the literature, providing inconclusive results. We present a case of a confirmed vertical transmission in a monochorial diamniotic twin pregnancy complicated by a selective intrauterine growth restriction (sIUGR) and gestational diabetes. The analysis of different biological specimens identifies the presence of SARS-CoV2 genome in the umbilical cord blood of both twins and the placental histologic examination confirmed indirect signs of viral infection, supporting the hypothesis that a transplacental infection can occur. Despite the devastating impact that SARS-CoV2 has worldwide, neonatal infections have been infrequently reported but they can occur under certain biologic conditions. A deep knowledge of the biological mechanisms underlying the risk of SARS-CoV-2 vertical transmission might be useful to understand the pathophysiological bases and the possible long-term implication of a mother-to-child vertical transmission.

SARS-CoV-2 vertical transmission in a twin-pregnant woman. A case report / Sessa, Rosa; Masciullo, Luisa; Filardo, Simone; DI PIETRO, Marisa; Brandolino, Gabriella; Brunelli, Roberto; Galoppi, Paola; Terrin, Gianluca; Viscardi, MARIA FEDERICA; Anastasi, Emanuela; Porpora, Maria Grazia. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 125:(2022), pp. 192-194. [10.1016/j.ijid.2022.10.019]

SARS-CoV-2 vertical transmission in a twin-pregnant woman. A case report

Rosa, Sessa;Luisa, Masciullo;Simone, Filardo
;
Marisa, Di Pietro;Gabriella, Brandolino;Roberto, Brunelli;Paola, Galoppi;Gianluca, Terrin;Maria Federica, Viscardi;Emanuela, Anastasi;Maria Grazia, Porpora
2022

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) has affected millions of people around the world in the last years. Among susceptible patients, pregnant women seem to be prone to have serious complications. The possibility of SARS-CoV-2 vertical transmission represents one of the most debated topics in the literature, providing inconclusive results. We present a case of a confirmed vertical transmission in a monochorial diamniotic twin pregnancy complicated by a selective intrauterine growth restriction (sIUGR) and gestational diabetes. The analysis of different biological specimens identifies the presence of SARS-CoV2 genome in the umbilical cord blood of both twins and the placental histologic examination confirmed indirect signs of viral infection, supporting the hypothesis that a transplacental infection can occur. Despite the devastating impact that SARS-CoV2 has worldwide, neonatal infections have been infrequently reported but they can occur under certain biologic conditions. A deep knowledge of the biological mechanisms underlying the risk of SARS-CoV-2 vertical transmission might be useful to understand the pathophysiological bases and the possible long-term implication of a mother-to-child vertical transmission.
2022
obstetric outcomes; placenta; pregnancy; sars-cov-2 infection; vertical transmission
01 Pubblicazione su rivista::01i Case report
SARS-CoV-2 vertical transmission in a twin-pregnant woman. A case report / Sessa, Rosa; Masciullo, Luisa; Filardo, Simone; DI PIETRO, Marisa; Brandolino, Gabriella; Brunelli, Roberto; Galoppi, Paola; Terrin, Gianluca; Viscardi, MARIA FEDERICA; Anastasi, Emanuela; Porpora, Maria Grazia. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 125:(2022), pp. 192-194. [10.1016/j.ijid.2022.10.019]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1657402
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