An otherwise healthy 72-year-old Chinese patient diagnosed with exudative age-related macular degeneration and decreased vision in left eye was fully investigated. The retrospective analysis of past multimodal imaging revealed bilateral severe choroidal neovascularization and choroiditis associated with a positive tuberculin skin testing and interferon-gamma release assay (QuantiFERON-TB Gold-Cellestis (R), Chadstone, VIC, Australia) suggestive of latent ocular tuberculosis. The variable presentation and tests' results interpretation represent the greatest limitations in understanding and treating intraocular TB (IOTB). This may present without any other systemic symptoms, the intraocular tissues are of limited access to biopsies and other tests, including imaging and immunological tests, are of relative value. This case highlights how variable may be the presentation of IOTB, which can be easily misdiagnosed leading to a delayed treatment and worse prognosis. (C) 2021 The Author(s). Published by S. Karger AG, Basel
Intraocular tuberculosis: a challenging case mimicking wet age-related macular degeneration / Interlandi, Emanuela; Pellegrini, Francesco; Pavesio, Carlos; Marco De Luca, ; Rocco De Marco, ; Papayannis, Alessandro; Mandara, Erika; Cuna, Alessandra; Cirone, Daniele; Ciabattoni, Cristina; Liberali, Tatiana; Zappacosta, Antonio; Latanza, Loredana. - In: CASE REPORTS IN OPHTHALMOLOGY. - ISSN 1663-2699. - 12:2(2021), pp. 519-524. [10.1159/000512578]
Intraocular tuberculosis: a challenging case mimicking wet age-related macular degeneration
Erika Mandara;
2021
Abstract
An otherwise healthy 72-year-old Chinese patient diagnosed with exudative age-related macular degeneration and decreased vision in left eye was fully investigated. The retrospective analysis of past multimodal imaging revealed bilateral severe choroidal neovascularization and choroiditis associated with a positive tuberculin skin testing and interferon-gamma release assay (QuantiFERON-TB Gold-Cellestis (R), Chadstone, VIC, Australia) suggestive of latent ocular tuberculosis. The variable presentation and tests' results interpretation represent the greatest limitations in understanding and treating intraocular TB (IOTB). This may present without any other systemic symptoms, the intraocular tissues are of limited access to biopsies and other tests, including imaging and immunological tests, are of relative value. This case highlights how variable may be the presentation of IOTB, which can be easily misdiagnosed leading to a delayed treatment and worse prognosis. (C) 2021 The Author(s). Published by S. Karger AG, Basel| File | Dimensione | Formato | |
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