Inflammation, which triggers the release of a variety of growth factors, cytokines, and chemokines, is a critical component of tumor progression. Prokineticin 2 belongs to a new family of chemokines bound to two G-protein -coupled receptors called prokineticin receptor 1 and 2 that exert various tissue-specific biological functions. Under pathological conditions, prokineticin 2 can induce the proliferation, migration, and angiogenesis of endothelial cells, suggesting that this molecule plays a role in tumor growth, angiogenesis, and metastasis.The aim of this review is to provide a complete compendium of the involvement of prokineticin 2 in some cancers and to evaluate its role not only in the tumor microenvironment as an angiogenic factor and a mediator of immune cell migration, but also in modulating tumor growth and spread as a suppressor of tumor cell apoptosis, and as a trigger of their proliferation and movements required for metastasis. The involvement of prokineticin 2 in tumor pain and resistance responses is also described, and finally, the potential role of pro-kineticin 2 as a novel prognostic tumor biomarker is highlighted.

Prokineticin 2 in cancer-related inflammation / Lattanzi, Roberta; Severini, Cinzia; Miele, Rossella. - In: CANCER LETTERS. - ISSN 0304-3835. - 546:(2022), p. 215838. [10.1016/j.canlet.2022.215838]

Prokineticin 2 in cancer-related inflammation

Lattanzi, Roberta
;
Miele, Rossella
2022

Abstract

Inflammation, which triggers the release of a variety of growth factors, cytokines, and chemokines, is a critical component of tumor progression. Prokineticin 2 belongs to a new family of chemokines bound to two G-protein -coupled receptors called prokineticin receptor 1 and 2 that exert various tissue-specific biological functions. Under pathological conditions, prokineticin 2 can induce the proliferation, migration, and angiogenesis of endothelial cells, suggesting that this molecule plays a role in tumor growth, angiogenesis, and metastasis.The aim of this review is to provide a complete compendium of the involvement of prokineticin 2 in some cancers and to evaluate its role not only in the tumor microenvironment as an angiogenic factor and a mediator of immune cell migration, but also in modulating tumor growth and spread as a suppressor of tumor cell apoptosis, and as a trigger of their proliferation and movements required for metastasis. The involvement of prokineticin 2 in tumor pain and resistance responses is also described, and finally, the potential role of pro-kineticin 2 as a novel prognostic tumor biomarker is highlighted.
2022
Angiogenesis; chemokines; drug resistance; G protein-coupled receptors; tumor biomarkers; tumor-induced pain; endothelial cells; gastrointestinal hormones; humans; inflammation; neoplasms; neuropeptides; tumor microenvironment
01 Pubblicazione su rivista::01a Articolo in rivista
Prokineticin 2 in cancer-related inflammation / Lattanzi, Roberta; Severini, Cinzia; Miele, Rossella. - In: CANCER LETTERS. - ISSN 0304-3835. - 546:(2022), p. 215838. [10.1016/j.canlet.2022.215838]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1655237
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