The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response.
The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults / Oliveto, Giuseppe; Scagnolari, Carolina; Frasca, Federica; Sorrentino, Leonardo; Matera, Luigi; Nenna, Raffaella; Viscido, Agnese; Scordio, Mirko; Petrarca, Laura; Maria Zicari, Anna; Gentilini, Elio; D'Ettorre, Gabriella; Ceccarelli, Giancarlo; Midulla, Fabio; Antonelli, Guido; Pierangeli, Alessandra. - In: CYTOKINE. - ISSN 1043-4666. - 158:(2022), pp. 1-5. [10.1016/j.cyto.2022.155997]
The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults
Oliveto, Giuseppe
;Scagnolari, Carolina;Frasca, Federica;Sorrentino, Leonardo;Matera, Luigi;Nenna, Raffaella;Viscido, Agnese;Scordio, Mirko;Petrarca, Laura;Maria Zicari, Anna;Gentilini, Elio;D'Ettorre, Gabriella;Ceccarelli, Giancarlo;Midulla, Fabio;Antonelli, Guido;Pierangeli, Alessandra
2022
Abstract
The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response.File | Dimensione | Formato | |
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