In cancer therapy, photodynamic technique (PDT) has attracted growing attention during the past decades. Among the drugs employed in PDT, 5-aminolevulinic acid (ALA) is one of their most effective ones due to its nontoxicity and quick excretion from the body. Despite the clinical significance of ALA, its application is sometimes restricted by its low chemical stability and its high hydrophilicity which result in the low penetration into cancer cells [1]. To improve the therapeutic efficacy of this drug, considerable efforts have been devoted to use inorganic-based nanodelivery systems [2]. To enhance the phototherapeutic efficacy of the nanoparticles-ALA conjugate (NPs-ALA), it is worth employing the photodynamic-active nanoparticles such as TiO2NPs. Low toxicity, chemical inertness, and biocompatibility of TiO2NPs make them suitable candidates for phototherapeutic studies. The aim of the project is to load ALA on the surface of polymer functionalized-TiO2NPs and their characterizations with UV-VIS, FT-IR, DLS and SEM techniques.

Loading of phototherapeutic drug 5-aminolevulinic acid on TiO2 nanoparticles: a new approach for potential dual phototherapeutic effects / Placitelli, Francesca Ilaria; Hajareh Haghighi, Farid; Mercurio, Martina; Fratoddi, Ilaria. - (2022). ((Intervento presentato al convegno The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) tenutosi a Rome, Italy.

Loading of phototherapeutic drug 5-aminolevulinic acid on TiO2 nanoparticles: a new approach for potential dual phototherapeutic effects

Francesca Ilaria Placitelli;Farid Hajareh Haghighi;Martina Mercurio;Ilaria Fratoddi
2022

Abstract

In cancer therapy, photodynamic technique (PDT) has attracted growing attention during the past decades. Among the drugs employed in PDT, 5-aminolevulinic acid (ALA) is one of their most effective ones due to its nontoxicity and quick excretion from the body. Despite the clinical significance of ALA, its application is sometimes restricted by its low chemical stability and its high hydrophilicity which result in the low penetration into cancer cells [1]. To improve the therapeutic efficacy of this drug, considerable efforts have been devoted to use inorganic-based nanodelivery systems [2]. To enhance the phototherapeutic efficacy of the nanoparticles-ALA conjugate (NPs-ALA), it is worth employing the photodynamic-active nanoparticles such as TiO2NPs. Low toxicity, chemical inertness, and biocompatibility of TiO2NPs make them suitable candidates for phototherapeutic studies. The aim of the project is to load ALA on the surface of polymer functionalized-TiO2NPs and their characterizations with UV-VIS, FT-IR, DLS and SEM techniques.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1650125
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