Purpose; Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This systematic review aimedto investigate the efficacy of colchicine, indomethacin, and dexamethasone in the treatment and prophylaxis of PPS. Methods: Literature research was carried out using PubMed. Studies investigating ≥ 10 patients with clinically PPS treatedwith colchicine, dexamethasone, and indomethacin and compared with placebo were included. Animal or in vitro experi-ments, studies on < 10 patients, case reports, congress reports, and review articles were excluded. Cochrane risk-of-bias toolfor randomized trials (RoB2) was used for the quality assessment of studies. Results: Seven studies were included. Among studies with postoperative colchicine treatment, two of them demonstrated asignificant reduction of PPS. In the single pre-surgery colchicine administration study, a decrease of PPS cases was registered.Indomethacin pre-surgery administration was linked to a reduction of PPS. No significant result emerged with preoperativedexamethasone intake. Conclusion; Better outcomes have been registered when colchicine and indomethacin were administered as primary prophy-lactic agents in preventing PPS and PE. Further RCT studies are needed to confirm these results

Treatment and prophylaxis of post-pericardiotomy syndrome in cardiac surgery patients. a systematic review / Giacinto, Omar; Minati, Alessandro; Lusini, Mario; Cardetta, Francesco; Saltarocchi, Sara; D'Abramo, Mizar; Miraldi, Fabio; Chello, Massimo. - In: CARDIOVASCULAR DRUGS AND THERAPY. - ISSN 0920-3206. - Sep 2021(2021). [10.1007/s10557-021-07261-4]

Treatment and prophylaxis of post-pericardiotomy syndrome in cardiac surgery patients. a systematic review.

Sara Saltarocchi
;
Mizar D’Abramo;Fabio Miraldi;
2021

Abstract

Purpose; Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This systematic review aimedto investigate the efficacy of colchicine, indomethacin, and dexamethasone in the treatment and prophylaxis of PPS. Methods: Literature research was carried out using PubMed. Studies investigating ≥ 10 patients with clinically PPS treatedwith colchicine, dexamethasone, and indomethacin and compared with placebo were included. Animal or in vitro experi-ments, studies on < 10 patients, case reports, congress reports, and review articles were excluded. Cochrane risk-of-bias toolfor randomized trials (RoB2) was used for the quality assessment of studies. Results: Seven studies were included. Among studies with postoperative colchicine treatment, two of them demonstrated asignificant reduction of PPS. In the single pre-surgery colchicine administration study, a decrease of PPS cases was registered.Indomethacin pre-surgery administration was linked to a reduction of PPS. No significant result emerged with preoperativedexamethasone intake. Conclusion; Better outcomes have been registered when colchicine and indomethacin were administered as primary prophy-lactic agents in preventing PPS and PE. Further RCT studies are needed to confirm these results
2021
post-pericardiotomy syndrome, colchicine, indomethacin, dexamethasone
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Treatment and prophylaxis of post-pericardiotomy syndrome in cardiac surgery patients. a systematic review / Giacinto, Omar; Minati, Alessandro; Lusini, Mario; Cardetta, Francesco; Saltarocchi, Sara; D'Abramo, Mizar; Miraldi, Fabio; Chello, Massimo. - In: CARDIOVASCULAR DRUGS AND THERAPY. - ISSN 0920-3206. - Sep 2021(2021). [10.1007/s10557-021-07261-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1650035
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