The aim of this work was to optimize and characterize nanocomposite films based on gellan gum methacrylate (GG-MA) and silver nanoparticles (AgNPs) for application in the field of wound dressing. The films were produced using the solvent casting technique coupled with a photocuring process. The UV irradiation of GG-MA solutions containing glycerol as a plasticizer and different amounts of silver nitrate resulted in the concurrent crosslinking of the photocurable polymer and a reduction of Ag ions with consequent in situ generation of AgNPs. In the first part of the work, the composition of the films was optimized, varying the concentration of the different components, the GG-MA/glycerol and GG-MA/silver nitrate weight ratios as well as the volume of the film-forming mixture. Rheological analyses were performed on the starting solutions, whereas the obtained films were characterized for their mechanical properties. Colorimetric analyses and swelling studies were also performed in order to determine the AgNPs release and the water uptake capacity of the films. Finally, microbiological tests were carried out to evaluate the antimicrobial efficacy of the optimized films, in order to demonstrate their possible application as dressings for the treatment of infected hard-to-heal wounds, which is a demanding task for public healthcare.

Solvent casting and UV photocuring for easy and safe fabrication of nanocomposite film dressings / DI MUZIO, Laura; Simonetti, Prisca; Carriero, VITO COSIMO; Brandelli, Chiara; Trilli, Jordan; Sergi, Claudia; Tirillo', Jacopo; Cairone, Francesco; Cesa, Stefania; Radocchia, Giulia; Schippa, Serena; Petralito, Stefania; Paolicelli, Patrizia; Casadei, Maria Antonietta. - In: MOLECULES. - ISSN 1420-3049. - 27:9(2022). [10.3390/molecules27092959]

Solvent casting and UV photocuring for easy and safe fabrication of nanocomposite film dressings

Laura Di Muzio;Prisca Simonetti;Vito Cosimo Carriero;Chiara Brandelli;Jordan Trilli;Claudia Sergi;Jacopo Tirillò;Francesco Cairone;Stefania Cesa;Giulia Radocchia;Serena Schippa;Stefania Petralito;Patrizia Paolicelli;Maria Antonietta Casadei
2022

Abstract

The aim of this work was to optimize and characterize nanocomposite films based on gellan gum methacrylate (GG-MA) and silver nanoparticles (AgNPs) for application in the field of wound dressing. The films were produced using the solvent casting technique coupled with a photocuring process. The UV irradiation of GG-MA solutions containing glycerol as a plasticizer and different amounts of silver nitrate resulted in the concurrent crosslinking of the photocurable polymer and a reduction of Ag ions with consequent in situ generation of AgNPs. In the first part of the work, the composition of the films was optimized, varying the concentration of the different components, the GG-MA/glycerol and GG-MA/silver nitrate weight ratios as well as the volume of the film-forming mixture. Rheological analyses were performed on the starting solutions, whereas the obtained films were characterized for their mechanical properties. Colorimetric analyses and swelling studies were also performed in order to determine the AgNPs release and the water uptake capacity of the films. Finally, microbiological tests were carried out to evaluate the antimicrobial efficacy of the optimized films, in order to demonstrate their possible application as dressings for the treatment of infected hard-to-heal wounds, which is a demanding task for public healthcare.
2022
antimicrobial activity; colorimetry; gellan gum methacrylate; photocuring; silver nanoparticles; solvent casting; thin film; wound dressings; anti-bacterial agents; bandages; glycerol; silver; silver nitrate; solvents; metal nanoparticles; nanocomposites
01 Pubblicazione su rivista::01a Articolo in rivista
Solvent casting and UV photocuring for easy and safe fabrication of nanocomposite film dressings / DI MUZIO, Laura; Simonetti, Prisca; Carriero, VITO COSIMO; Brandelli, Chiara; Trilli, Jordan; Sergi, Claudia; Tirillo', Jacopo; Cairone, Francesco; Cesa, Stefania; Radocchia, Giulia; Schippa, Serena; Petralito, Stefania; Paolicelli, Patrizia; Casadei, Maria Antonietta. - In: MOLECULES. - ISSN 1420-3049. - 27:9(2022). [10.3390/molecules27092959]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1645551
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