Prokineticin-2 (PK2) is a chemokine-like peptide abundantly expressed in the central nervous system (CNS), involved in multiple physiological and pathological conditions, which acts as an insult-inducible endangering mediator contributing to cellular defence.1 Of relevance, PK2 is highly induced during early phases of dopaminergic degeneration in Parkinson’s disease (PD), activating a neuroprotective response by the PGC-1αmediated restoration of mitochondrial function
Increase of prokineticin-2 in serum of patients with parkinson's disease / Schirinzi, T.; Maftei, D.; Pieri, M.; Bernardini, S.; Mercuri, N. B.; Lattanzi, R.; Severini, C.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - (2021), pp. 1-2. [10.1002/mds.28458]
Increase of prokineticin-2 in serum of patients with parkinson's disease
Maftei D.Methodology
;Lattanzi R.Conceptualization
;
2021
Abstract
Prokineticin-2 (PK2) is a chemokine-like peptide abundantly expressed in the central nervous system (CNS), involved in multiple physiological and pathological conditions, which acts as an insult-inducible endangering mediator contributing to cellular defence.1 Of relevance, PK2 is highly induced during early phases of dopaminergic degeneration in Parkinson’s disease (PD), activating a neuroprotective response by the PGC-1αmediated restoration of mitochondrial function| File | Dimensione | Formato | |
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