Prokineticin-2 (PK2) is a chemokine-like peptide abundantly expressed in the central nervous system (CNS), involved in multiple physiological and pathological conditions, which acts as an insult-inducible endangering mediator contributing to cellular defence.1 Of relevance, PK2 is highly induced during early phases of dopaminergic degeneration in Parkinson’s disease (PD), activating a neuroprotective response by the PGC-1αmediated restoration of mitochondrial function
Increase of Prokineticin-2 in Serum of Patients with Parkinson's Disease / Schirinzi, T.; Maftei, D.; Pieri, M.; Bernardini, S.; Mercuri, N. B.; Lattanzi, R.; Severini, C.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 36:4(2021), pp. 1031-1033. [10.1002/mds.28458]
Increase of Prokineticin-2 in Serum of Patients with Parkinson's Disease
Maftei D.Methodology
;Lattanzi R.Conceptualization
;
2021
Abstract
Prokineticin-2 (PK2) is a chemokine-like peptide abundantly expressed in the central nervous system (CNS), involved in multiple physiological and pathological conditions, which acts as an insult-inducible endangering mediator contributing to cellular defence.1 Of relevance, PK2 is highly induced during early phases of dopaminergic degeneration in Parkinson’s disease (PD), activating a neuroprotective response by the PGC-1αmediated restoration of mitochondrial functionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
