Background: Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking. Methods: A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex-and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: <50–60, 61–70, and >70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H2 O2 ), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed. Results: Nox2 activity and H2 O2 production were higher in the AF patients than in the CS; conversely, antioxidant capacity was decreased in the AF patients compared to the CS, as was NO production. Moreover, sP-selectin and CD40L were higher in the AF patients than in the CS. The autophagy process was also significantly impaired in the AF patients. We found a significant difference in oxidative stress, PA, NO production, and autophagy across the age groups. Autophagy markers correlated with oxidative stress, PA, and endothelial dysfunction in both groups. Conclusions: This study provides evidence that the autophagy process may represent a mechanism for increased cardiovascular risk in the AF population.

Aging-Related Decline of Autophagy in Patients with Atrial Fibrillation—A Post Hoc Analysis of the ATHERO-AF Study / Versaci, F.; Valenti, V.; Forte, M.; Cammisotto, V.; Nocella, C.; Bartimoccia, S.; Schirone, L.; Schiavon, S.; Vecchio, D.; D'Ambrosio, L.; Spinosa, G.; D'Amico, A.; Chimenti, I.; Violi, F.; Frati, G.; Pignatelli, P.; Sciarretta, S.; Pastori, D.; Carnevale, R.. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 11:4(2022), pp. 1-11. [10.3390/antiox11040698]

Aging-Related Decline of Autophagy in Patients with Atrial Fibrillation—A Post Hoc Analysis of the ATHERO-AF Study

Valenti V.;Cammisotto V.;Nocella C.;Bartimoccia S.;Schirone L.;Schiavon S.;Vecchio D.;D'ambrosio L.;Chimenti I.;Violi F.;Frati G.;Pignatelli P.;Sciarretta S.;Pastori D.
;
Carnevale R.
2022

Abstract

Background: Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking. Methods: A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex-and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: <50–60, 61–70, and >70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H2 O2 ), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed. Results: Nox2 activity and H2 O2 production were higher in the AF patients than in the CS; conversely, antioxidant capacity was decreased in the AF patients compared to the CS, as was NO production. Moreover, sP-selectin and CD40L were higher in the AF patients than in the CS. The autophagy process was also significantly impaired in the AF patients. We found a significant difference in oxidative stress, PA, NO production, and autophagy across the age groups. Autophagy markers correlated with oxidative stress, PA, and endothelial dysfunction in both groups. Conclusions: This study provides evidence that the autophagy process may represent a mechanism for increased cardiovascular risk in the AF population.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1628838
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